Pathologic Changes of Aorta and Coronary Arteries of Mice Infected with Coxsackie B4 Virus 1
Pathologic Changes of Aorta and Coronary Arteries of Mice Infected with Coxsackie B4 Virus 1
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柯萨奇B4病毒1型感染小鼠主动脉和冠状动脉的病理变化
DOI：
10.3181/00379727-137-35641
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发表时间：
1971
影响因子：
--
通讯作者：
J. Harb
中科院分区：
文献类型：
--
作者：
G. Burch;C. Tsui;J. Harb
研究表明，科萨基B4病毒可在2日龄和12日龄小鼠的大血管和小血管中产生显著病变。感染科萨基病毒B4的小鼠出现局灶性内皮细胞变性和坏死，随后主动脉、冠状动脉、大静脉和其他血管内膜脱落和剥脱。病毒感染在人类中很常见，但大血管感染的研究仍然很少。病毒病变被认为是人类血管疾病（可能包括动脉粥样硬化）产生的起始因素。
Summary Coxsackie virus B4 has been shown to produce significant lesions in the large and small blood vessels of 2-day-old and 12-day-old mice. The Coxsackie virus B4-infected mice developed focal endothelial cell degeneration and necrosis with subsequent desquamation and denudation of intima of the aorta, coronary arteries, large veins, and other blood vessels. Viral infections in man are common, but infection of the great blood vessels remains little studied. Viral lesions are suggested as an initiating factor in the production of vascular diseases in man, possibly including atherosclerosis.