The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.
The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.
复制标题
DOI：
10.1186/s12890-018-0705-6
复制
发表时间：
2018-08-20
影响因子：
3.1
通讯作者：
ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)
中科院分区：
文献类型：
--
作者：
Fuchs O;Bahmer T;Weckmann M;Dittrich AM;Schaub B;Rösler B;Happle C;Brinkmann F;Ricklefs I;König IR;Watz H;Rabe KF;Kopp MV;Hansen G;von Mutius E;ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)
儿童期和成人期哮喘和喘息障碍在疾病表现、自然病程和治疗反应方面具有临床异质性。在不同的亚组中破译常见的疾病机制需要在前瞻性的纵向环境中协调儿童和成人哮喘患者的分子（endo-）表型。德国肺研究中心（DZL）的全年龄哮喘队列（ALLIANCE）是一项前瞻性、多中心、观察性队列研究，在德国有7个招募点。数据来自四个来源：(a)病历中的患者病史，(b)标准化问卷调查和结构化访谈，(c)电话访谈，以及(d)客观测量。客观测量包括肺功能和气道炎症和呼气、外周血、皮肤、鼻、咽和鼻咽拭子、鼻分泌物、原代鼻上皮细胞和诱导痰的定量评估。在某些情况下，定期进行客观测量和生物材料收集，而对照受试者仅在基线时检查一次。标准化和详细的流行病学和生理学数据收集，以及在所有年龄的相当数量的研究参与者中广泛的生物材料的分子深度表型是该多中心队列的突出特征。尽管进行了广泛的生物材料取样，并且招聘策略也包括6个月大的学龄前儿童，但损耗率很低。儿童83.9%，成人90.5%参加了12个月的随访。然而，最早纳入病例的时间点是疾病表现。因此，揭示驱动疾病发病的机制是有限的，因为这个问题只能在以人口为基础的出生队列中得到回答。尽管如此，ALLIANCE提供了一个独特的、综合的、跨学科的框架，以跨年龄的前瞻性和相同的方式，以确定不同儿童喘息和哮喘轨迹的生物标志物和预测因子，以及它们在成年期的进一步病程。最终，该方法旨在将其最重要的发现转化为临床实践，并改善哮喘从青春期到成年期的过渡。NCT02496468用于儿童手臂，NCT02419274用于成人手臂。
Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to treatment. Deciphering common disease mechanisms in distinct subgroups requires harmonized molecular (endo-) phenotyping of both children and adult patients with asthma in a prospective, longitudinal setting. The ALL Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL) is a prospective, multi-center, observational cohort study with seven recruiting sites across Germany. Data are derived from four sources: (a) patient history from medical records, (b) standardized questionnaires and structured interviews, (c) telephone interviews, and (d) objective measurements. Objective measurements include amongst others lung function and quantitative assessment of airway inflammation and exhaled breath, peripheral blood, skin, nasal, pharyngeal, and nasopharyngeal swabs, nasal secretions, primary nasal epithelial cells, and induced sputum. In cases, objective measurements and biomaterial collection are performed regularly, while control subjects are only examined once at baseline. The standardized and detailed collection of epidemiological and physiological data, and the molecular deep phenotyping of a comprehensive range of biomaterials in a considerable number of study participants across all ages are the outstanding characteristics of this multi-center cohort. Despite extensive biomaterial sampling, and a recruitment strategy that also includes pre-school children as young as 6 months, attrition is low. In children 83.9%, and in adults 90.5% attended the 12-month follow-up. The earliest time-point to include cases, however, is disease manifestation. Therefore, unraveling mechanisms that drive disease onset is limited, as this question can only be answered in a population-based birth cohort. Nonetheless, ALLIANCE offers a unique, integrative and inter-disciplinary framework with a comprehensive molecular approach in a prospective and identical fashion across ages in order to identify biomarkers and predictors for distinct childhood wheeze and asthma trajectories as well as their further course during adulthood. Ultimately, this approach aims to translate its most significant findings into clinical practice, and to improve asthma transition from adolescence to adulthood. NCT02496468 for pediatric arm, NCT02419274 for adult arm.
登录
查看更多内容
影响因子：
5.8
作者：
Meyer N;Dallinga JW;Nuss SJ;Moonen EJ;van Berkel JJ;Akdis C;van Schooten FJ;Menz G
通讯作者：
Menz G
影响因子：
3.7
作者：
Hennig, Christian;Adams, Nico;Hansen, Gesine
通讯作者：
Hansen, Gesine
影响因子：
9.6
作者：
Bickel, Scott;Popler, Jonathan;Eid, Nemr
通讯作者：
Eid, Nemr
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society