The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.
The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.
复制标题
DOI：
10.1016/j.bbrc.2004.11.016
复制
发表时间：
2004-12
影响因子：
3.1
通讯作者：
Hiroaki Suzuki;M. Kurita;K. Mizumoto;M. Moriyama;S. Aiso;I. Nishimoto;M. Matsuoka
中科院分区：
文献类型：
--
作者：
Hiroaki Suzuki;M. Kurita;K. Mizumoto;M. Moriyama;S. Aiso;I. Nishimoto;M. Matsuoka
ARF抑癌基因拮抗多种肿瘤的产生。 ARF 介导的肿瘤抑制以 p53 独立方式和 p53 依赖方式发生。我们在此证明 BCL6 是 ARF 肿瘤抑制因子的靶标。小鼠 p19AR 或人 p14ARF 均与 BCL6 结合并下调 BCL6 诱导的转录抑制。 ARF 介导的 BCL6 活性下调可能部分解释了 ARF 介导的肿瘤抑制。
The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19ARFor human p14ARFbinds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.