3-DIMENSIONAL INVIVO MAPPING OF BRAIN-LESIONS IN HUMANS
3-DIMENSIONAL INVIVO MAPPING OF BRAIN-LESIONS IN HUMANS
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DOI：
10.1001/archneur.1992.00530260037016
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发表时间：
1992-02-01
影响因子：
--
通讯作者：
FRANK, R
中科院分区：
文献类型：
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作者：
DAMASIO, H;FRANK, R
我们描述了一个多步骤的技术，在体内的脑病变的三维重建和分析的基础上获得的磁共振原始数据的操作与一个特殊的协议。该技术允许直接视觉识别的神经解剖标志在每个大脑标本，并消除了需要依赖于平均模板的人脑切片，这可能是一个来源的病变定位误差。该技术还允许在二维切片和体积重建中的数据点之间的双向交叉参考，以及将皮质下结构投影到三维皮质表面上。三维病变标测技术可用于人和非人灵长类动物的病变方法研究、神经外科病变入路的规划以及神经解剖学的教学。
We describe a multistep technique for three-dimensional reconstruction and analysis of brain lesions in vivo, based on the manipulation of magnetic resonance raw data obtained with a special protocol. The technique permits the direct visual identification of neuronantomical landmarks in each brain specimen and eliminates the need to rely on averaged templates of human brain sections, which can be a source of lesion localization error. The technique also allows for the bidrectional cross-reference between data points in two-dimensional slices and in volume reconstruction and for the projection of subcortical structures onto the three-dimensional cortical surface. The three-dimensional lesion mapping technique can be applied to research with the lesion method in both human and nonhuman primates, to the planning of neurosurgical lesion approach, and to the teaching of neuroanatomy.