CRP Level and HDL Cholesterol Concentration Jointly Predict Mortality in a Korean Population
CRP Level and HDL Cholesterol Concentration Jointly Predict Mortality in a Korean Population
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DOI：
10.1016/j.amjmed.2012.02.013
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发表时间：
2012-08-01
影响因子：
5.9
通讯作者：
Kim, Suhnggwon
中科院分区：
文献类型：
--
作者：
Kim, Kwang-Il;Oh, Se Won;Kim, Suhnggwon
背景：C反应蛋白（CRP）和高密度脂蛋白（HDL）胆固醇是众所周知的心血管预测因子。然而，这些参数对长期死亡率的联合影响尚未确定。方法：我们研究了总共 92,500 名 20 岁以上受试者，他们在首尔国立大学附属的三个保健中心接受了常规健康检查。在基线时获得高敏 CRP 和血脂谱。受试者的随访时间中位数为 45.5 个月。死亡率数据来自韩国国家统计局。结果：随访期间有 649 人死亡（0.7%）。死亡的主要原因是癌症。死亡的受试者年龄明显较大，男性占多数，并且炎症标志物水平升高。根据 CRP 和 HDL 胆固醇水平确定了显着的死亡率差异。综合考虑这两个参数，CRP >= 1.4 mg/L（最高四分位）和 HDL 胆固醇的受试者
BACKGROUND: C-reactive protein (CRP) and high-density lipoprotein (HDL) cholesterol are well-known cardiovascular predictors. However, the joint effect of these parameters on long-term mortality has not been established.METHODS: We studied a total of 92,500 subjects older than 20 years who underwent routine health examination at the three health care centers affiliated with Seoul National University. High-sensitivity CRP and the lipid profile were obtained at baseline. Subjects were followed for a median of 45.5 months. Mortality data were obtained from the National Statistics Office of Korea.RESULTS: There were 649 deaths (0.7%) during the follow-up. The leading cause of death was cancer. The subjects who died were significantly older, had a male predominance, and had increased levels of inflammatory markers. A significant mortality difference was identified according to the CRP and HDL cholesterol levels. Considering both parameters jointly, subjects with a CRP >= 1.4 mg/L (highest quartile) and HDL cholesterol