Flavan-3-ols consumption and cancer risk: A meta-analysis of epidemiologic studies.
Flavan-3-ols consumption and cancer risk: A meta-analysis of epidemiologic studies.
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Flavan-3-ols 消耗量与癌症风险：流行病学研究的荟萃分析
DOI：
10.18632/oncotarget.12017
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发表时间：
2016-11-08
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
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作者：
Lei L;Yang Y;He H;Chen E;Du L;Dong J;Yang J
尽管大量体外研究和动物模型数据表明，黄烷-3-醇（饮食中最常见的类黄酮）可能对癌症产生保护作用，但流行病学研究报告了黄烷-3-醇摄入量与癌症风险之间的关联的不确定性结果。因此，我们对流行病学研究进行了荟萃分析，以调查黄烷-3-醇对各种类型癌症的预防作用。共纳入43项流行病学研究，包括25项病例对照研究和18项前瞻性队列研究。黄烷-3-醇摄入量与总体癌症风险呈显著负相关（相对风险（RR）0.935，95%CI：0.891-0.981）。当单独分析癌症类型时，在直肠癌中观察到黄烷-3-醇消耗具有统计学显着的保护作用（RR 0.838，95%CI：0.733-0.958），口咽癌和喉癌乳腺癌（RR 0.885，95%CI：0.790 - 0.991）和女性胃癌（RR 0.633，95%CI：0.468-0.858）。我们的分析表明黄烷-3-醇在预防癌症方面的潜在益处。
Although numerous in vitro studies and animal model data have suggested that flavan-3-ols, the most common subclass of flavonoids in the diet, may exert protective effects against cancer, epidemiologic studies have reported inconclusive results for the association between flavan-3-ols intake and cancer risk. Therefore, we conducted this meta-analysis of epidemiologic studies to investigate the preventive effects of flavan-3-ols on various types of cancers. A total of 43 epidemiologic studies, consisting of 25 case-control and 18 prospective cohort studies, were included. A significant inverse association was shown between flavan-3-ols intake and the risk of overall cancer (relative risk (RR) 0.935, 95%CI: 0.891-0.981). When cancer types were separately analyzed, a statistically significant protective effect of flavan-3-ols consumption was observed in rectal cancer (RR 0.838, 95%CI: 0.733-0.958), oropharyngeal and laryngeal cancer (RR 0.759, 95%CI: 0.581-0.993), breast (RR 0.885, 95%CI: 0.790-0.991) in case-control studies and stomach cancer in women (RR 0.633, 95%CI: 0.468-0.858). Our analysis indicates the potential benefits of flavan-3-ols in cancer prevention.