Smoking as a risk factor for visceral fat accumulation in Japanese men
Smoking as a risk factor for visceral fat accumulation in Japanese men
复制标题
DOI：
10.1620/tjem.208.123
复制
发表时间：
2006-02-01
影响因子：
2.2
通讯作者：
Tajima, N
中科院分区：
文献类型：
--
作者：
Komiya, H;Mori, Y;Tajima, N
流行病学和临床研究表明，吸烟、体力活动和饮酒是肥胖的危险因素。然而，关于吸烟对内脏型肥胖的影响，目前还没有达成共识。本研究旨在评估吸烟是否与内脏脂肪、葡萄糖和脂质代谢的积累有关。研究对象为450名24 ~ 68岁的男性，在公司定期进行的健康检查中，在健康控制中心接受检查。采用自填式问卷调查确定吸烟状况、日常体力活动和饮酒情况。Brinkman指数作为吸烟状况的指标与内脏脂肪面积（VFA）呈正相关。在Brinkman指数较高的吸烟者中，体重指数、VFA、甘油三酯、高密度脂蛋白-胆固醇、动脉粥样硬化指数、血糖、免疫反应性胰岛素、胰岛素抵抗稳态模型（HOMA-IR）异常者的百分比高于非吸烟者。当评估VFA ≥ 100 cm（2）发生率的年龄调整优势比时，饮酒与最高优势比相关。吸烟、缺乏运动和过量饮酒与内脏型肥胖有关，吸烟影响糖脂代谢。总之，这些研究结果表明，吸烟是内脏脂肪堆积和糖脂代谢恶化的危险因素。
Epidemiological and clinical studies on the lifestyle-related obesity have identified smoking, physical activity and alcohol intake as risk factors for obesity. However, no consensus has yet been reached on the effect of smoking on visceral adiposity. This Study was designed to assess whether smoking is associated with the accumulation of visceral fat, glucose and lipid metabolism. The subjects were 450 males aged from 24 to 68 years old, who were examined at the health control center in the regular health check conducted by their company. A self-administered questionnaire was used to ascertain smoking status, daily physical activity and alcohol drinking. The number of Brinkman index as an index for smoking status was positively related to being visceral fat area (VFA). In smokers whose Brinkman index was higher, the perk cent Of Subjects with abnormal body mass index, VFA, triglyceride, high density lipoprotein-cholesterol, atherosclerotic index, plasma glucose, immunoreactive insulin, or homeostasis model assessment of insulin resistance (HOMA-IR) was higher than that in non-smokers. When evaluated in terms of age-adjusted odds ratios for incidence of a VFA of 100 cm(2) or greater, alcohol drinking was associated with the highest odds ratio. Smoking, physical inactivity and excessive alcohol drinking were associated with visceral adiposity, and smoking affected glucose and lipid metabolism. In conclusions, these findings suggest that smoking is a risk factor for visceral fat accumulation and deterioration Of glucose and lipid metabolism.