Specific Obesity-related Adipokines
Specific Obesity-related Adipokines
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特定的肥胖相关脂肪因子
DOI：
10.4172/2469-9756.1000108
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发表时间：
2015
影响因子：
4.6
通讯作者：
H. R. Frigeri
中科院分区：
文献类型：
--
作者：
G. Z. Candido;Isabelle Leticia Zaboroski Silva;Laysa Toschi Martins;Letícia Koczicki;K. Kubo;H. R. Frigeri
肥胖被定义为异常或过度的脂肪积累，对健康构成风险[1]。脂肪组织最重要的相关成分是脂肪酸，但脂肪细胞可能会分泌免疫成分，如前列腺素。在过去的12年里，脂肪组织通过分泌具有生物效应的分子的能力而发挥的内分泌作用也被发现。此外，许多研究人员认为这种组织是参与各种代谢和生理过程的动态器官[2]。除此之外，脂肪细胞可能会分泌各种称为脂肪因子的生物活性多肽。脂肪组织的过度生长可能导致脂肪细胞肥大，从而导致脂肪因子分泌的改变。
Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health [1]. The most important associated elements of this tissue are the fatty acids, however the adipocytes might secrete immunological components, such as prostaglandins. In the last 12 years, the endocrine role of the adipose tissue by its ability to secrete molecules with biological effects has also been discovered. Furthermore, this tissue was considered, by many researchers, as a dynamic organ involved in a variety of metabolic and physiological processes [2]. Apart from that, adipocytes might secrete a variety of bioactive peptides called adipokines. An alteration on adipokines secretion can be caused by excessive growth of adipose tissue, which can leads to adipocyte hypertrophy [3].