Quantitative Analysis and Design of a Spray Aerosol Inhaler. Part 1: Effects of Dilution Air Inlets and Flow Paths
Quantitative Analysis and Design of a Spray Aerosol Inhaler. Part 1: Effects of Dilution Air Inlets and Flow Paths
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DOI：
10.1089/jamp.2008.0739
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发表时间：
2009-09-01
影响因子：
3.4
通讯作者：
Hindle, Michael
中科院分区：
文献类型：
--
作者：
Longest, P. Worth;Hindle, Michael
背景资料：本研究的目的是评估修改吸入器的设计变量对气雾剂药物沉积在吸嘴内的代表性喷雾system.Methods的定量分析和设计方法的影响：毛细管气溶胶生成（CAG）被选为一个模型喷雾气雾剂系统结合四个原型吸入器的身体和吸嘴组合。体外实验用于测定吸嘴和诱导端口中的药物沉积。验证计算流体动力学（CFD）模拟实施，以建立设计变量，运输特性和气雾剂药物deposit.Results之间的关系：本研究的结果表明，上游稀释空气入口的大小和喷嘴附近的流路配置显着影响气雾剂的运输和沉积。CFD结果表明，与药物沉积相关的主要传输特性是湍流强度和吸嘴的有效直径。强定量相关性之间的确定的运输特性和喉舌药物deposit.Conclusions：定量分析和设计的基础上，湍流强度和有效喉舌直径被确定为设计空间内的关键运输特性，直接影响气溶胶沉积，并可用于预测和优化药物输送到病人。
Background: The objective of this study was to evaluate the effects of modifying inhaler design variables on aerosol drug deposition within the mouthpiece for a representative spray system using a quantitative analysis and design approach.Methods: Capillary aerosol generation (CAG) was selected as a model spray aerosol system in conjunction with four prototype inhaler body and mouthpiece combinations. In vitro experiments were used to determine drug deposition in the mouthpiece and induction port. Validated computational fluid dynamics (CFD) simulations were implemented to establish relationships between design variables, transport characteristics, and aerosol drug deposition.Results: Results of this study indicated that both the size of the upstream dilution air inlets and the flow pathway configuration near the spray nozzle significantly influenced aerosol transport and deposition. CFD results showed that the primary transport characteristics associated with drug deposition were turbulence intensity and the effective diameter of the mouthpiece. Strong quantitative correlations were developed between the identified transport characteristics and mouthpiece drug deposition.Conclusions: Based on quantitative analysis and design, turbulence intensity and effective mouthpiece diameter were identified as key transport characteristics within the design space that directly influenced aerosol deposition and may be used to predict and optimize drug delivery to the patient.