Age-Related Cataract Is Associated with Type 2 Diabetes and Statin Use
Age-Related Cataract Is Associated with Type 2 Diabetes and Statin Use
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DOI：
10.1097/opx.0b013e3182644cd1
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发表时间：
2012-08-01
影响因子：
1.4
通讯作者：
Irving, Elizabeth L.
中科院分区：
文献类型：
--
作者：
Machan, Carolyn M.;Hrynchak, Patricia K.;Irving, Elizabeth L.
目的。糖尿病已被证明是年龄相关性白内障（AR）的危险因素。由于他汀类药物（HMG-CoA还原酶抑制剂）目前常用于2型糖尿病患者，因此应考虑其对AR性白内障患病率的影响。本研究确定了AR白内障、2型糖尿病和他汀类药物在大量验光临床人群中的使用之间的关系。总共有6397例患者（38岁），其中2型糖尿病患者占56%，非糖尿病患者占16%。2型糖尿病与核硬化（OR = 1.62, 1.14-2.29）和皮质性白内障（OR = 1.37, 1.02-1.83）显著相关。他汀类药物的使用与核硬化（OR = 1.48, 1.09-2.00）和后囊膜下白内障（OR = 1.48, 1.07-2.04）相关。他汀类药物使用者白内障的50%概率分别发生在51.7岁和54.9岁的2型糖尿病和非糖尿病患者中。在非他汀类药物使用者中，2型糖尿病患者和非糖尿病患者分别在55.1岁和57.3岁时出现明显延迟（p < 0.001）。在这个人群中，他汀类药物的使用在2型糖尿病患者中明显更高，并且与AR白内障相关。有必要进行进一步的长期研究，以推荐对他汀类药物受益的2型糖尿病患者进行晶状体监测。（光学视觉科学2012；89:1165-1171）
Purpose. Diabetes has been shown to be a risk factor for age-related (AR) cataract. As statins (HMG-CoA reductase inhibitors) are now commonly prescribed for patients with type 2 diabetes, their impact on AR cataract prevalence should be considered. This study determines associations between AR cataract, type 2 diabetes, and reported statin use in a large optometric clinic population.Methods. In all, 6397 patient files (ages 38 years) was 56% for those with type 2 diabetes and 16% for those without diabetes. Type 2 diabetes was significantly associated with nuclear sclerosis (OR = 1.62, 1.14-2.29) and cortical cataract (OR = 1.37, 1.02-1.83). Statin use was associated with nuclear sclerosis (OR = 1.48, 1.09-2.00) and posterior subcapsular cataract (OR = 1.48, 1.07-2.04). The 50% probability of cataract in statin users occurred at age 51.7 and 54.9 years in patients with type 2 diabetes and without diabetes, respectively. In non-statin users, it was significantly later at age 55.1 and 57.3 years for patients with type 2 diabetes and without diabetes, respectively (p < 0.001).Conclusions. In this population, statin use was substantially higher in patients with type 2 diabetes and was associated with AR cataracts. Further long-term study is warranted to recommend monitoring of crystalline lenses in patients with type 2 diabetes benefiting from statins. (Optom Vis Sci 2012; 89:1165-1171)