Zebrafish models of human liver development and disease.
Zebrafish models of human liver development and disease.
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DOI：
10.1002/cphy.c120021
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发表时间：
2013-07
影响因子：
5.8
通讯作者：
Pack M
中科院分区：
文献类型：
--
作者：
Wilkins BJ;Pack M
肝脏执行大量必需的合成和调节功能，这些功能在胎儿发育期间获得并持续整个生命。它们的破坏是影响儿童和成人患者的各种遗传性和获得性疾病的基础。虽然用于研究肝脏发育和疾病的实验分析通常在细胞培养模型或啮齿动物中进行，但斑马鱼越来越多地用于补充这些系统中的发现。在过去的二十年中，正向和反向遗传分析表明，肝脏发育的分子程序在斑马鱼和哺乳动物之间基本上是保守的，并且斑马鱼可用于模拟可遗传的人类肝脏疾病。最近的工作表明，斑马鱼也可以用于研究获得性肝病的机制基础。在这里，我们提供了一个全面的总结，斑马鱼如何有助于我们了解人类肝脏发育和疾病。
The liver performs a large number of essential synthetic and regulatory functions that are acquired during fetal development and persist throughout life. Their disruption underlies a diverse group of heritable and acquired diseases that affect both pediatric and adult patients. Although experimental analyses used to study liver development and disease are typically performed in cell culture models or rodents, the zebrafish is increasingly used to complement discoveries made in these systems. Forward and reverse genetic analyses over the past two decades have shown that the molecular program for liver development is largely conserved between zebrafish and mammals, and that the zebrafish can be used to model heritable human liver disorders. Recent work has demonstrated that zebrafish can also be used to study the mechanistic basis of acquired liver diseases. Here, we provide a comprehensive summary of how the zebrafish has contributed to our understanding of human liver development and disease.