AMPHETAMINE POTENTIATION OF ANTICONFLICT ACTION OF CHLORDIAZEPOXIDE
AMPHETAMINE POTENTIATION OF ANTICONFLICT ACTION OF CHLORDIAZEPOXIDE
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DOI：
10.1016/0091-3057(86)90345-x
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发表时间：
1986-02-01
影响因子：
3.6
通讯作者：
MYSLOBODSKY, MS
中科院分区：
文献类型：
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作者：
LERNER, T;FELDON, J;MYSLOBODSKY, MS
采用改良的Geller-Seifter范式，在雄性白化大鼠中测试亚阈剂量安非他明和氯二氮环氧化物（CDP）单独或联合给药对休克诱导的食物增强杠杆按压抑制的影响。MK-801，一种新合成的具有抗焦虑和抗惊厥特性的拟交感神经药物，也进行了测试。0.1、0.2、0.3和1.0 mg/kg剂量的dl-安非他明没有抗焦虑和致焦虑作用，但1.0 mg/kg剂量的dl-安非他明增加了非冲突反应。0.1、0.2和0.4 mg/kg剂量的CDP对冲突和非冲突反应无显著影响。0.8 mg/kg剂量的CDP有增加冲突反应的倾向。安非他明（0.2 mg/kg）和CDP （0.4 mg/kg）联合给药具有显著的抗冲突作用。MK-801在50亩。G /kg和100 .mu。G /kg导致非冲突反应显著增加。MK-801在50亩。G /kg也具有显著的抗冲突作用。从可能增强去甲肾上腺素能或多巴胺能活性及其在GABA-苯二氮平偶联位点与GABA神经传递的相互作用方面讨论了安非他明与CDP共给药的去抑制作用。
A modified Geller-Seifter paradigm was employed to test in male albino rats the effects of subthreshold doses of amphetamine and chlordiazepoxide (CDP), administered separately or in combination, on shock induced suppression of food-reinforced lever-pressing. MK-801, a newly synthesized sympathomimetic with anxiolytic and anticonvulsant properties, was also tested. dl-Amphetamine in doses of 0.1, 0.2, 0.3 and 1.0 mg/kg had no anxiolytic nor anxiogenic effects, but at 1.0 mg/kg it increased non-conflict responding. CDP in doses of 0.1, 0.2, and 0.4 mg/kg had no significant effect on conflict and non-conflict responding. CDP in the dose of 0.8 mg/kg tended to increase conflict responding. Coadministration of amphetamine (0.2 mg/kg) and CDP (0.4 mg/kg) had a significant anti-conflict effect. MK-801 at 50 .mu.g/kg and 100 .mu.g/kg caused a significant increase in non-conflict responding. MK-801 at 50 .mu.g/kg exerted also a significant anti-conflict effect. The disinhibitor effects of amphetamine coadministered with CDP were discussed in terms of a possible enhanced noradrenergic or dopaminergic activity and their interaction with GABA neurotransmission at GABA-benzodiazepine coupled sites.