The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing
The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing
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DOI：
10.1016/j.biomaterials.2007.09.015
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发表时间：
2008-01-01
期刊：
影响因子：
14
通讯作者：
Muratoglu, Orhun K.
中科院分区：
文献类型：
--
作者：
Bodugoz-Senturk, Hatice;Choi, Jeeyoung;Muratoglu, Orhun K.
聚（乙烯醇）（PVA）水凝胶是用于软骨表面重修或插入式关节成形术装置的候选生物材料，需要高抗蠕变性和高含水量以保持润滑性。 PVA 的退火提高了抗蠕变性，但也降低了水含量。我们假设在退火过程中将聚乙二醇 (PEG) 保留在 PVA 中可以防止孔塌陷，从而导致高平衡水含量 (EWC)。我们的假设得到了验证。含有 PEG 的 PVA 水凝胶通过退火保持其不透明性，并在共焦成像下显示出大孔，而不含 PEG 的水凝胶在退火后变成半透明且看不到孔。使用 PEG 退火的凝胶的 EWC (83 +/- 1.0%) 高于未使用 PEG 处理的凝胶 (55 +/- 4.8)。前者的结晶度为8.0+/-1.7%，后者为27.5+/-8.7%。在 0.45 MPa 的初始接触应力下，与不含 PEG 的水凝胶 (17 + 3.7) 相比，在 PEG 存在下加工的水凝胶表现出显着更高的总蠕变应变 (69 +/- 3.4%)。 EWC 似乎与退火 PVA θ 凝胶的抗蠕变性密切相关。 (C) 2007 Elsevier Ltd. 保留所有权利。
Poly(vinyl alcohol) (PVA) hydrogels are candidate biomaterials for cartilage resurfacing or interpositional arthroplasty devices requiring high-creep resistance and high water content to maintain lubricity. Annealing of PVA improves creep resistance but also reduces the water content. We hypothesized that maintaining poly(ethylene glycol) (PEG) within PVA during annealing would prevent the collapse of the pores and thus would result in high equilibrium water content (EWC). Our hypothesis tested positive. The PVA hydrogels containing PEG maintained their opacity through annealing and exhibited large pores under confocal imaging while hydrogels not containing PEG turned translucent and no pores were visible after annealing. The EWC of gels annealed with PEG (83 +/- 1.0%) was higher than that of the gels processed without PEG (55 +/- 4.8). The crystallinity of the former was 8.0 +/- 1.7% and the latter was 27.5 +/- 8.7%. The hydrogels processed in the presence of PEG exhibited a significantly higher total creep strain (69 +/- 3.4%) when compared to the PEG-free hydrogels (17 + 3.7) under an initial contact stress of 0.45 MPa. EWC appeared to be strongly related to the creep resistance of annealed PVA theta-gels. (C) 2007 Elsevier Ltd. All rights reserved.