IL-10: An "immunologic scalpel" for atherosclerosis?
IL-10: An "immunologic scalpel" for atherosclerosis?
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IL-10：治疗动脉粥样硬化的“免疫手术刀”？
DOI：
10.1161/01.atv.19.12.2823
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Terkeltaub,RA
中科院分区：
文献类型：
--
作者：
Terkeltaub,RA
单核白细胞介导的炎症是动脉粥样硬化的中心特征。研究人员通过减少病变单核细胞募集和巨噬细胞介导的炎症反应，发现这些特异性事件对动脉粥样硬化病变的发展和进展至关重要。病变T淋巴细胞具有活化的表型，并与病变巨噬细胞共定位，特别是在疾病早期。然而，损伤T淋巴细胞在动脉粥样硬化形成中的作用不如巨噬细胞的作用那么清楚。
Mononuclear leukocyte–mediated inflammation is a central feature of atherosclerosis. Using measures that diminish lesion monocyte recruitment and macrophage-mediated inflammation, investigators have shown these specific events to be essential to the development and progression of atherosclerotic lesions. Lesion T lymphocytes have an activated phenotype and colocalize with lesion macrophages, particularly in early disease. However, the role of lesion T lymphocytes in atherogenesis is not as well understood as the role of macrophages.