Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury
Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury
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DOI：
10.1016/j.joca.2016.09.008
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发表时间：
2017-04-01
影响因子：
7
通讯作者：
Struglics, A.
中科院分区：
文献类型：
--
作者：
Neuman, P.;Dahlberg, L. E.;Struglics, A.
目的：描述释放的纵向模式，并研究急性和慢性阶段的一组滑液生物标志物与前交叉韧带 (ACL) 损伤后放射学膝骨关节炎 (OA) 发展之间的关联。设计：在 88 名患者中，在前 2 周内（急性样本）从急性 ACL 损伤的膝盖中抽吸滑液，并在受伤后 7.5 年内每年抽吸一次（慢性样本）。受试者（60% 为男性）。未受伤的受试者 (n = 12) 用作参考组。通过免疫分析对滑液中的聚集蛋白聚糖、软骨寡聚基质蛋白 (COMP)、基质金属蛋白酶 (MMP)-3 和金属蛋白酶组织抑制剂 (TIMP)-1 进行定量。 ACL 损伤后 16 年，通过负重膝关节 X 线检查，检查是否存在放射学胫股骨 (TF) 或髌股骨 (PF) OA 倒置垂直垂直线 Kellgren 和 Lawrence (K&L) >= 2 倒置提升垂直线。 结果：与参考组相比，COMP 和聚集蛋白聚糖的平均急性和慢性 SF 浓度升高（P < 0.001）。 COMP和聚集蛋白聚糖的水平在ACL损伤后约半年明显下降，并在随访7.5年期间恢复到参考值。使用逻辑回归分析，四种生物标志物的急性和慢性浓度均与 16 年随访时放射学膝关节 OA 的发生无关。结论：聚集蛋白聚糖和 COMP 滑液浓度增加与膝关节损伤相关，但聚集蛋白聚糖、COMP、MMP-3 和 TIMP-1 的急性和慢性滑液浓度未能预测 ACL 损伤后 16 年的膝关节 OA。 (C) 2016 年国际骨关节炎研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To describe the longitudinal patterns of release, and investigate the association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury.Design: Synovial fluid was aspirated from the acutely ACL-injured knee within the first 2weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral (TF) or patellofemoral (PF) OA inverted right perpendicular Kellgren and Lawrence (K&L) >= 2 inverted lift perpendicular was examined with weight-bearing knee radiography 16 years after the ACL injury.Results: The average acute and chronic SF concentrations of COMP and aggrecan were elevated in comparison with the reference group (P < 0.001). The levels of COMP and aggrecan clearly decreased approximately half a year after the ACL injury, and returned to reference values during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the development of radiographic knee OA at the 16 year follow-up.Conclusion: Increased synovial fluid concentrations of aggrecan and COMP was related to knee injury, but acute and chronic synovial fluid concentrations of aggrecan, COMP, MMP-3 and TIMP-1 failed to predict knee OA 16 years after ACL injury. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.