Acute Graft‐Versus‐Host Disease of the Large Intestine after Bone Marrow Transplantation

Acute Graft‐Versus‐Host Disease of the Large Intestine after Bone Marrow Transplantation
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骨髓移植后大肠急性移植物抗宿主病

DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
H. Saito
H. Saito
中科院分区：
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文献类型：
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作者：
J. Haruta;K. Kusugami;T. Yamaguchi;Masafumi Ito;Y. Oka;A. Kusakabe;N. Takeda;K. Nobata;H. Saito

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摘要： 一名13岁男性患有急性淋巴细胞白血病，入院接受骨髓移植（BMT）。 BMT 后第四周出现下腹疼痛和血性腹泻。结肠镜检查显示直肠和乙状结肠粘膜水肿、糜烂和多发不规则溃疡。组织学上，在隐窝基底膜中可以识别出多个凋亡病变。大多数浸润淋巴细胞是带有 LFA-1a-、CD43 和 CD45RO 抗原的成熟记忆 T 淋巴细胞。血管内皮细胞出现 HLA-DR 和 ICAM-1 免疫染色，上皮细胞 HLA-DR 抗原染色呈阳性。
Abstract: A 13‐year old male with acute lymphocytic leukemia was admitted to our hospital for bone marrow transplantation (BMT). Lower abdominal pain and bloody diarrhea developed during the fourth post‐BMT week. Colonoscopy revealed edematous mucosa, erosions and multiple irregular ulcers in the rectum and sigmoid colon. Histologically, multiple apoptotic lesions were recognizable in the crypt basement membrane. Most infiltrating lymphoid cells were mature memory T lymphocytes bearing LFA‐la‐, CD43 and CD45RO antigens. HLA‐DR and ICAM‐1 immunostaining was seen on the vascular endothelium and the epithelium stained positively for HLA‐DR antigens.