ENTERIC COLONIZATION IN SPORADIC NEONATAL NECROTIZING ENTEROCOLITIS
ENTERIC COLONIZATION IN SPORADIC NEONATAL NECROTIZING ENTEROCOLITIS
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DOI：
10.1097/00005176-198508000-00017
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发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
BARNES, GL
中科院分区：
文献类型：
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作者：
BLAKEY, JL;LUBITZ, L;BARNES, GL
在新生儿散发性坏死性小肠结肠炎（NEC）发病时，研究了肠道菌群。25例NEC患儿的肠道植物群与23例对照组存在差异。拟杆菌属与对照组相比，NEC患儿中乳杆菌的检出率较低：分别为32%和61%（P = 0.03），12%和48%（P = 0.006）。40%的NEC患儿分离出产气荚膜梭菌，而对照组为13%（P = 0.03）。33%的NEC < 14天的婴儿中存在，但在相同年龄的对照婴儿中未检测到。结果：C. butyricum和C.艰难梭菌在患者和对照组中相似。C.定殖在缺乏保护性屏障植物群的情况下产气荚膜原在严重突发NEC的发病机制中可能是关键的。预测这种形式的散发性NEC发作的两个潜在有价值的标志物因素是粪便涂片的使用和粪便胰蛋白酶活性的估计。
Microflora of the gut was studied close to the onset of sporadic necrotizing enterocolitis (NEC) in neonates. Enteric flora in 25 babies with NEC differed from that in 23 matched controls. Bacteriodes spp. and lactobacilli were less common in babies with NEC compared with controls: 32 vs. 61% (P = 0.03) and 12 vs. 48% (P = 0.006), respectively. Clostridium perfringens was isolated from 40% of babies with NEC compared with 13% of control (P = 0.03). It was present in 33% of babies with NEC < 14 days old but was not detected in control babies of the same age. The incidences of C. butyricum and C. difficile were similar in patients and controls. Colonization with C. perfringens in the absence of a protective barrier flora may be crucial in the pathogenesis of severe sudden onset NEC. Two potentially valuable marker factors to predict onset of this form of sporadic NEC are the use of fecal smears and estimation of fecal tryptic activity.