Cholinergic, adrenergic and purinergic response of sequential strips of rabbit urinary bladder.
Cholinergic, adrenergic and purinergic response of sequential strips of rabbit urinary bladder.
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兔膀胱连续条带的胆碱能、肾上腺素能和嘌呤能反应。
DOI：
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发表时间：
1980
影响因子：
3.5
通讯作者：
A. Wein
中科院分区：
文献类型：
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作者：
R. Levin;F. Shofer;A. Wein
在这项研究中，我们描述了膀胱五个连续节段对胆碱能、肾上腺素能和嘌呤能激动剂的反应。结果表明，膀胱体和基底部之间的药理反应的突然改变发生在输尿管口的水平。膀胱体优先响应尿胆碱（毒蕈碱胆碱能）、异丙肾上腺素（β 肾上腺素能）和 ATP（嘌呤能），而膀胱基部优先响应甲氧胺（α 肾上腺素能）。在平行研究中，体内毒蕈碱胆碱能受体（[3H]苯苯甲酸奎宁环酯结合位点）和β肾上腺素能受体的密度均显着高于基底，而膀胱基底中α肾上腺素能受体的浓度则高于体内。从这些研究中，我们得出结论，膀胱底部和身体对胆碱能和肾上腺素能药物的反应差异主要是由于特定自主神经受体密度的差异。此外，膀胱对 ATP（膀胱中假定的神经递质）的反应也可以在身体和基底之间分开。该分布与观察到的尿胆碱分布相似。
In this study, we have characterized the response of five sequential segments of urinary bladder to cholinergic, adrenergic, and purinergic agonists. The results indicate that an abrupt alteration in pharmacological response between bladder body and base occurs at the level of the ureteral orifices. The bladder body responds preferentially to urecholine (muscarinic cholinergic), isoproterenol (beta adrenergic) and ATP (purinergic), whereas the bladder base responds perferentially to methoxamine alpha adrenergic). In parallel studies, the density of both muscarinic cholinergic receptors ([3H]quinuclidinyl benzilate binding sites) and beta adrenergic receptors were significantly higher in the body than in the base, whereas the concentration of alpha adrenergic receptors was greater in the bladder base than in the body. From these studies, we conclude that the differences in the response of the bladder base and body to cholinergic and adrenergic agents are primarily due to differences in the densities of the specific autonomic receptors. In addition, the response of the bladder to ATP (which is a putative neurotransmitter in the urinary bladder) can also be separated between body and base. The distribution is similar to that observed for urecholine.