Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells.
Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells.
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DOI：
10.1016/j.smim.2011.06.001
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发表时间：
2011-12
影响因子：
7.8
通讯作者：
Cantor H
中科院分区：
文献类型：
--
作者：
Kim HJ;Cantor H
建立对病原体的有效免疫应答，同时避免对宿主组织的损伤是免疫系统的中心任务。新出现的证据强调了调节性T细胞的CD 8+谱系对维持自身耐受性的贡献。调节性CD 8 + T细胞对与活化的CD 4 + T细胞表达的肽复合的MHC Ib类分子Qa-1的特异性识别触发了防止自身免疫应答的抑制性相互作用。相反，缺陷的Qa-1限制性CD 8+调节活性可导致系统性自身免疫性疾病的发展。在这里，我们回顾了最近的研究，这些调节性T细胞的细胞和分子基础，其抑制活性的机制和潜在的应用这些见解到新的治疗自身免疫性疾病和癌症。
Mounting an efficient immune response to pathogens while avoiding damage to host tissues is the central task of the immune system. Emerging evidence has highlighted the contribution of the CD8+ lineage of regulatory T cells to the maintenance of self-tolerance. Specific recognition of the MHC class Ib molecule Qa-1 complexed to peptides expressed by activated CD4+ T cells by regulatory CD8+ T cells triggers an inhibitory interaction that prevents autoimmune responses. Conversely, defective Qa-1-restricted CD8+ regulatory activity can result in development of systemic autoimmune disease. Here, we review recent research into the cellular and molecular basis of these regulatory T cells, their mechanism of suppressive activity and the potential application of these insights into new treatments for autoimmune disease and cancer.