Association of socioeconomic status with arterial stiffness in older African American and White adults: The ARIC study cohort.
Association of socioeconomic status with arterial stiffness in older African American and White adults: The ARIC study cohort.
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DOI：
10.1016/j.ajpc.2023.100469
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发表时间：
2023-03
影响因子：
4.1
通讯作者：
Alonso, Alvaro
中科院分区：
文献类型：
--
作者：
Spikes, Telisa A;Alam, Aniqa B;Lewis, Tene T;Gwen Windham, B;Kucharska-Newton, Anna;Alonso, Alvaro
在一个老年非裔美国人和白色成年人队列中，研究SES教育程度和家庭收入的个体测量的横截面关联，以及SES与PWV的联合效应，以及SES种族相互作用。来自社区动脉粥样硬化风险（ARIC）研究的数据被用来评估个体和关节SES [教育和收入]与颈动脉股动脉脉搏波速度（cfPWV）（动脉硬度的亚临床标志物）的横断面相关性，以及SES和种族的相互作用，使用调整后的多变量线性回归模型，对3342名67岁至69岁的男性和女性进行了队列研究。2011-2013年89年无CVD。64%的受试者为女性，23%为非洲裔美国人，平均cfPWV（12.3±3.5-非洲裔美国人和11.6±3.9-白色受试者）。与高中以下相比，研究生教育与非洲裔美国人（β = -1.28 m/s; 95% CI，-1.97，-0.59）的cfPWV较低（僵硬度较低）显著相关，但与白色受试者（β = -0.69 m/s; 95% CI，-1.39，0.01）无关。与<25 K美元相比，收入≥ 5万美元与非洲裔美国人（β = -0.82 m/s; 95% CI，-1.42，-0.22）和白色（β = -0.76 m/s; 95% CI，-1.19，-0.32）参与者的cfPWV较低相关。在非裔美国人和白色成年人中，种族和SES个体测量值对cfPWV的相互作用在统计学上不显著（p值>0.10）。在该队列中，较高的SES与较低的动脉硬度相关;数据不支持种族差异。需要对SES和cfPWV进行前瞻性研究，以有效地比较具有更广泛社会经济特征的更大种族和地区多样性人群，从而更好地识别亚组CVD风险。
To examine the cross-sectional associations of individual measures of SES—educational attainment and household income—and the joint effects of SES with PWV, as well as the SES-race interaction, in a cohort of older African American and White adults. Data from the Atherosclerosis Risk in Communities (ARIC) Study were used to evaluate the cross-sectional associations of individual and joint SES [education and income] and carotid femoral pulse wave velocity (cfPWV), a subclinical marker of arterial stiffness, and the interaction of SES and race using adjusted multivariable linear regression models in a cohort of 3342 men and women aged 67–89 years free of CVD in 2011–2013. Participants were 64% female, 23% African American, mean cfPWV (12.3±3.5-African American and 11.6±3.9-White participants). Post-graduate education compared to less than high school was significantly associated with lower cfPWV (less stiffness) in African American (β = -1.28 m/s; 95% CI, -1.97, -0.59) but not in White (β = -0.69 m/s; 95% CI, -1.39, 0.01) participants. Income ≥$50K as compared to <$25K, was associated with lower cfPWV both in African American (β = -0.82 m/s; 95% CI, -1.42, -0.22) and White (β = -0.76 m/s; 95% CI, -1.19, -0.32) participants. The interaction of race and individual measures of SES on cfPWV in African American and White adults were not statistically significant (p-value >0.10). Higher SES was cross-sectionally associated with lower arterial stiffness in this cohort; the data did not support differences by race. Prospective studies of SES and cfPWV are needed to efficiently compare larger racially and regionally diverse populations with a wider range of socioeconomic profiles to better identify subgroup CVD risk.