RESISTANCE TO AMPHOTERICIN-B ASSOCIATED WITH DEFECTIVE STEROL DELTA(8-]7) ISOMERASE IN A CRYPTOCOCCUS-NEOFORMANS STRAIN FROM AN AIDS PATIENT
RESISTANCE TO AMPHOTERICIN-B ASSOCIATED WITH DEFECTIVE STEROL DELTA(8-]7) ISOMERASE IN A CRYPTOCOCCUS-NEOFORMANS STRAIN FROM AN AIDS PATIENT
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DOI：
10.1111/j.1574-6968.1994.tb07140.x
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发表时间：
1994-09-15
影响因子：
2.1
通讯作者：
POWDERLY, WG
中科院分区：
文献类型：
--
作者：
KELLY, SL;LAMB, DC;POWDERLY, WG
研究了从艾滋病患者分离的两株新型隐球菌，一株为治疗前分离株（CN 1），另一株为氟康唑和阿替霉素B治疗失败后分离株（CN 3）。氟康唑敏感性无差异，但观察到CN 3对阿替霉素B的相对耐药性。CN 3的甾醇组成表明，该菌株中甾醇δ（8->7）异构酶存在缺陷，并且CN 1的主要甾醇麦角甾醇耗尽。
Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Delta(8-->7) isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.