Intron-mediated regulation of gene expression.
Intron-mediated regulation of gene expression.
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DOI：
10.1007/978-3-540-76776-3_15
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发表时间：
2008
影响因子：
--
通讯作者：
A. Rose
中科院分区：
文献类型：
--
作者：
A. Rose
内含子可以以多种方式显著影响植物和许多其他真核生物中的基因表达。几种类型的基因调控，积极和消极的，涉及植物内含子在本章中进行了审查。一些内含子含有增强子元件或替代启动子，而许多其他内含子通过称为内含子介导增强（IME）的不同过程提高mRNA积累。IME中涉及的内含子必须位于基因起始附近的转录序列内，并处于其天然方向以增加表达。所涉及的内含子序列仍然不清楚，IME的机制仍然是个谜。IME的模型中，内含子增加转录延长。
Introns can significantly affect gene expression in plants and many other eukaryotes in a variety of ways. Several types of gene regulation, both positive and negative, that involve plant introns are reviewed in this chapter. Some introns contain enhancer elements or alternative promoters, while many others elevate mRNA accumulation by a different process that has been named intron-mediated enhancement (IME). The introns involved in IME must be within transcribed sequences near the start of a gene and in their natural orientation to increase expression. The intron sequences involved are still poorly defined, and the mechanism of IME remains mysterious. A model of IME is presented in which introns increase transcript elongation.