Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair.
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair.
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DOI：
10.3389/fcell.2016.00071
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发表时间：
2016
影响因子：
5.5
通讯作者：
Relvas JB
中科院分区：
文献类型：
--
作者：
Domingues HS;Portugal CC;Socodato R;Relvas JB
少突胶质细胞是中枢神经系统的髓鞘胶质细胞。轴突的髓鞘形成允许神经冲动的快速跳跃传导，并有助于轴突的完整性。多发性硬化症等脱髓鞘疾病造成的破坏性神经缺陷很好地说明了这一过程的重要性。在这篇综述中，我们集中在发育髓鞘形成和再髓鞘形成过程中少突胶质细胞、星形胶质细胞和小胶质细胞之间的正负相互作用。尽管许多证据支持胶质细胞串扰在这些过程中的关键作用，但在设计修复脱髓鞘损伤的治疗方法时，这种相互作用的性质往往被忽视。了解神经胶质细胞通讯的细胞和分子机制以及它们如何影响少突胶质细胞的分化和髓鞘形成是揭示髓鞘修复的新治疗策略的基础。
Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of axons allows rapid saltatory conduction of nerve impulses and contributes to axonal integrity. Devastating neurological deficits caused by demyelinating diseases, such as multiple sclerosis, illustrate well the importance of the process. In this review, we focus on the positive and negative interactions between oligodendrocytes, astrocytes, and microglia during developmental myelination and remyelination. Even though many lines of evidence support a crucial role for glia crosstalk during these processes, the nature of such interactions is often neglected when designing therapeutics for repair of demyelinated lesions. Understanding the cellular and molecular mechanisms underlying glial cell communication and how they influence oligodendrocyte differentiation and myelination is fundamental to uncover novel therapeutic strategies for myelin repair.