Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation
Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation
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DOI：
10.1101/lm.1918210
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发表时间：
2010-10-01
影响因子：
2
通讯作者：
Cain, Christopher K.
中科院分区：
文献类型：
--
作者：
Lazzaro, Stephanie C.;Hou, Mian;Cain, Christopher K.
Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued fear conditioning. Systemic or intra-lateral amygdala terazosin delivered before conditioning enhanced short-and long-term memory. Terazosin delivered after conditioning did not affect consolidation. In vitro, terazosin impaired lateral amygdala inhibitory postsynaptic currents leading to facilitation of excitatory postsynaptic currents and long-term potentiation. Since alpha1 blockers are prescribed for hypertension and post-traumatic stress disorder, these results may have important clinical implications.
