BAF Complexes and the Glucocorticoid Receptor in Breast Cancers.
BAF Complexes and the Glucocorticoid Receptor in Breast Cancers.
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DOI：
10.1016/j.coemr.2020.07.001
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发表时间：
2020-12
影响因子：
--
通讯作者：
Archer TK
中科院分区：
文献类型：
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作者：
Dietrich N;Hoffman JA;Archer TK
乳腺癌是一组不同的疾病，并且通常以它们表达激素如雌激素和孕酮的受体为特征。最近，另一种类固醇激素受体，糖皮质激素受体（GR）已被证明是乳腺癌进展，转移和治疗的关键球员。这些受体与染色质结合以引起细胞内的转录变化，这通常被染色质本身的结构抑制。染色质重塑蛋白，如Brahma相关基因1（BRG 1），功能是克服这种转录因子功能的物理抑制，并与许多癌症，包括乳腺癌。最近在乳腺癌中了解BRG 1和GR相互作用的努力，包括基因组和单细胞分析，可能会让人们深入了解个性化药物和其他潜在的治疗方法。
Breast cancers are a diverse group of diseases and are often characterized by their expression of receptors for hormones such as estrogen and progesterone. Recently another steroid hormone receptor, the glucocorticoid receptor (GR) has been shown to be a key player in breast cancer progression, metastasis, and treatment. These receptors bind to chromatin to elicit transcriptional changes within cells, which are often inhibited by the structure of chromatin itself. Chromatin remodeling proteins, such as Brahma-related gene 1 (BRG1), function to overcome this physical inhibition of transcription factor function and have been linked to many cancers including breast cancer. Recent efforts to understand the interactions of BRG1 and GR, including genomic and single cell analyses, within breast cancers may give insight into personalized medicine and other potential treatments.