Liver immunology and herbal treatment.
Liver immunology and herbal treatment.
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DOI：
10.4254/wjh.v9.i17.757
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发表时间：
2017-06-18
影响因子：
2.4
通讯作者：
Koca-Caliskan U
中科院分区：
文献类型：
--
作者：
Balaban YH;Aka C;Koca-Caliskan U
除了代谢功能，肝脏最近被定义为免疫系统（IS）的器官，它对先天性和适应性免疫具有中心调节作用。肝脏在对病原性抗原的肝脏筛选和对自身抗原的免疫耐受之间保持微妙的平衡。具有免疫效应的草药治疗有可能通过肝毒性或引发自身免疫性疾病诱导肝损伤，从而改变这种肝脏免疫平衡，使其偏向治疗侧或疾病侧。本文综述了近年来国内外通过体外、体内和/或临床研究证实的对肝脏和IS具有治疗作用的常用中药治疗方法。
Beyond the metabolic functions, the liver recently has been defined as an organ of immune system (IS), which have central regulatory role for innate and adaptive immunity. The liver keeps a delicate balance between hepatic screening of pathogenic antigens and immune tolerance to self-antigens. Herbal treatments with immunological effects have potential to alter this hepatic immune balance towards either therapeutic side or diseases side by inducing liver injury via hepatotoxicity or initiation of autoimmune diseases. Most commonly known herbal treatments, which have therapeutic effect on liver and IS, have proven via in vitro, in vivo, and/or clinical studies were summarized in this review.