Rapid access to the welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones
Rapid access to the welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones
复制标题
DOI：
10.1021/ol051239t
复制
发表时间：
2005-09-15
期刊：
影响因子：
5.2
通讯作者：
Simpkins, NS
中科院分区：
文献类型：
--
作者：
Baudoux, J;Blake, AJ;Simpkins, NS
通过酸介导的适当取代的吲哚醛的环闭合，建立了非常快速地获得环己酮桥连的吲哚系统，这涉及到一个明显的羟醛类中间体的缩合。桥连吲哚中间体之一被进一步转化成具有Welwitindolinone生物碱的基本骨架的羟吲哚。
A very rapid access to cyclohexanone-bridged indole systems was established by an acid-mediated ring closure of appropriately substituted indole aldehydes, which involved an apparent disproportionation of an aldol-like intermediate. One of the bridged indole intermediates was further transformed into an oxindole having the essential skeleton of the Welwitindolinone alkaloids.