Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation.
Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation.
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DOI：
10.1371/journal.pone.0004097
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Goldstein DR
中科院分区：
文献类型：
--
作者：
Shen H;Tesar BM;Du W;Goldstein DR
As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation. Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8+ T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging. Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation.
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影响因子：
15.9
作者：
Ordemann, R;Hutchinson, R;Ferrara, JLM
通讯作者：
Ferrara, JLM
影响因子：
4.4
作者：
Walker, Wendy E.;Nasr, Isam W.;Goldstein, Daniel R.
通讯作者：
Goldstein, Daniel R.
DOI：
10.1046/j.1532-5415.2002.50002.x
发表时间：
2002-01-01
影响因子：
6.3
作者：
Meier-Kriesche, HU;Cibrik, DM;Kaplan, B
通讯作者：
Kaplan, B
影响因子：
6.2
作者：
PIRSCH, JD;STRATTA, RJ;BELZER, FO
通讯作者：
BELZER, FO
影响因子：
5.4
作者：
ROSENBERG, AS;SECHLER, JMG;BLOOM, ET
通讯作者：
BLOOM, ET