Highly Selective Monoalkylation of Active Methylene and Related Derivatives using Alkylsilyl Peroxides by a Catalytic CuI-DMAP System
Highly Selective Monoalkylation of Active Methylene and Related Derivatives using Alkylsilyl Peroxides by a Catalytic CuI-DMAP System
复制标题
通过 CuI-DMAP 催化系统使用烷基甲硅烷基过氧化物对活性亚甲基及相关衍生物进行高选择性单烷基化
DOI：
10.1002/ajoc.202100440
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
and K. Maruoka
中科院分区：
文献类型：
--
作者：
C.-H. Zhou;J.-M. Lv;W.-P. Xu;H.-B. Lu;T. Kato;Y. Liu;and K. Maruoka
在温和条件下，利用不同类型的烷基硅基过氧化物在铜催化剂的存在下进行活性亚甲基及相关衍生物的高选择性单烷基化反应，已发展到具有综合应用价值的水平。这种方法在活性亚甲基化合物和烷基硅基过氧化物方面具有广泛的底物范围。此外，硝基烷烃还可用于铜催化烷基硅基过氧化物选择性单烷基化反应。通过机理研究，提出了自由基在单烷基化反应中的作用。
A new approach for highly selective monoalkylation of active methylene and related derivatives using various types of alkylsilyl peroxides in the presence of copper catalysts under mild conditions has been developed to a synthetically useful level. This approach has a wide substrate scope in terms of both active methylene compounds and alkylsilyl peroxides. In addition, nitroalkanes can also be employed for a copper‐catalyzed selective monoalkylation with alkylsilyl peroxides. The participation of radical species was proposed in the present monoalkylation reactions by the mechanistic study.