Cytotoxic and Antimicrobial Flavonoids from Cryptocarya concinna
Cytotoxic and Antimicrobial Flavonoids from Cryptocarya concinna
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厚壳桂具有细胞毒性和抗菌作用的黄酮类化合物
DOI：
10.1055/s-0034-1368613
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发表时间：
2014-07-01
期刊：
影响因子：
2.7
通讯作者：
Ge, Hui-Ming
中科院分区：
文献类型：
--
作者：
Huang, Wei;Zhang, Wen-Jing;Ge, Hui-Ming
从隐果核桃茎中分离得到5个新的黄酮类化合物，即隐酮A-E(1-5)和6个已知化合物(6-11)。通过光谱分析确定了化合物的结构，并通过圆二色谱和X-射线晶体分析确定了化合物的绝对构型。并对这些化合物的细胞毒性和抗菌活性进行了评价。化合物9和10对HCT116、HT-29、SW480和MDA-MB-231细胞具有中等的细胞毒活性，IC50值在6.25~9.35mU·M之间；化合物8和11对串珠镰刀菌和灰霉病菌有一定的抑菌活性，最小抑菌浓度为5mU·g/L。
Five new flavonoids, cryptoconones A-E (1-5), along with six known compounds (6-11), were isolated from the stems of Cryptocarya concinna. The structures of these compounds were elucidated on the basis of spectroscopic data interpretation, and the absolute configurations were determined via circular dichroism spectra and X-ray crystal analysis. The cytotoxic and antimicrobial activities of these compounds were also evaluated. Compounds 9 and 10 exhibited moderate cytotoxic activities against HCT116, HT-29, SW480, and MDA-MB-231 cell lines with IC50 values ranging from 6.25 to 9.35 mu M. Compounds 8 and 11 exhibited antimicrobial activity against Fusarium moniliforme and Botrytis cinerea, respectively, with the same minimum inhibitory concentration of 5 mu g/mL.