Individual differences in extraversion and dopamine genetics predict neural reward responses
Individual differences in extraversion and dopamine genetics predict neural reward responses
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DOI：
10.1016/j.cogbrainres.2005.09.018
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Ranganath, C
中科院分区：
文献类型：
--
作者：
Cohen, MX;Young, J;Ranganath, C
心理学家已经将人格特质外向性与奖励敏感性和多巴胺功能的差异联系起来，但很少有人知道这些差异如何反映在大脑多巴胺能神经奖励系统的功能中。在这里，我们表明，在外向性和多巴胺D2受体基因上的A1等位基因的存在的个体差异预测在赌博任务中大脑的奖励系统的激活幅度。在两项功能性MRI实验中，参与者在行为反应后立即（研究1）或在7.5秒预期期后（研究2）可能会收到奖励。虽然组激活地图显示的预期和奖励相关的激活奖励系统，在外倾性和D2 Taq1A等位基因的存在下的个体差异预测了显着量的奖励相关的，但不预期相关的，激活的幅度的主体间的变异性。这些结果表明，性格、遗传学和大脑功能的稳定差异之间存在联系。(c)2005 Elsevier B.V.保留所有权利。
Psychologists have linked the personality trait extraversion both to differences in reward sensitivity and to dopamine functioning, but little is known about how these differences are reflected in the functioning of the brain's dopaminergic neural reward system. Here, we show that individual differences in extraversion and the presence of the A1 allele on the dopamine D2 receptor gene predict activation magnitudes in the brain's reward system during a gambling task. In two functional MRI experiments, participants probabilistically received rewards either immediately following a behavioral response (Study 1) or after a 7.5 s anticipation period (Study 2). Although group activation maps revealed anticipation- and reward-related activations in the reward system, individual differences in extraversion and the presence of the D2 Taq1A allele predicted a significant amount of inter-subject variability in the magnitudes of reward-related, but not anticipation-related, activations. These results demonstrate a link between stable differences in personality, genetics, and brain functioning. (c) 2005 Elsevier B.V. All rights reserved.