CELLULAR DYNAMICS OF COMEDO FORMATION IN ACNE VULGARIS
CELLULAR DYNAMICS OF COMEDO FORMATION IN ACNE VULGARIS
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DOI：
10.1007/bf00595286
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
KLIGMAN, AM
中科院分区：
文献类型：
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作者：
PLEWIG, G;FULTON, JE;KLIGMAN, AM
使用皮内注射氚胸苷、甘氨酸和组氨酸后制备的放射自显影，比较了正常人和痤疮患者面部和背部的上皮周转率。测定了表皮、皮脂腺滤泡、开放粉刺和闭合粉刺中胸腺嘧啶核苷标记的百分比。随后，甘氨酸或组氨酸标记的角质细胞进入粉刺。在粉刺和非粉刺受试者之间没有发现细胞动力学上的差异。面部表皮的翻转速度几乎是背部表皮的两倍。毛囊的标记类似于邻近的表皮，粉刺的标记指数比正常皮脂腺毛囊大得多。细胞增殖在闭合状态下比开放状态下快，标记的角质细胞在椭圆形带中移动到开放状态的粉刺的物质中。标记的细胞最终从扩张的小孔中脱落出来。在最长观察时间(2个月)之前，闭合性粉刺没有发生这种情况。粉刺的形成是两种异常的结果：1.角质细胞的形成增加；2.连贯性增加。
Epithelial turnover was compared on the faces and backs of normal and acne subjects using autoradiographs prepared after intra-dermal injection of tritiated thymidine, glycine and histidine. The percentage of thymidine labelled nuclei in the epidermis, sebaceous follicles and open and closed comedones was determined. The movement of glycine or histidine labelled horny cells into comedones was followed.No differences in cellular kinetics were found between acne and non-acne subjects. Turnover of the facial epidermis was almost twice as fast as of the back epidermis. Follicle labelling was similar to the contiguous epidermis.The labelling index of the comedo was much greater than in the normal sebaceous follicle. Cellular multiplication was faster in closed than in open comedones.Labelled horny cells moved in an elliptical band into the substance of the open comedo. Labelled cells eventually sloughed through the patulous orifice. This did not happen in closed comedones up to the maximum time of observation (2 months).Comedo formation is the resultant of two abnormalities: 1. increased formation of horny cells and 2. increased coherence.