Altered blood flow in cerebral perforating arteries of rat models of diabetes: A synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities
Altered blood flow in cerebral perforating arteries of rat models of diabetes: A synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities
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糖尿病大鼠模型脑穿动脉血流改变：白质高信号临床评估的同步辐射微血管造影研究
DOI：
10.1111/ggi.12658
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Hidezo Mori
中科院分区：
文献类型：
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作者：
Naoto Fukuyama;Yuko Tsukamoto;Shunya Takizawa;Yoshimori Ikeya;Toshiharu Fujii;Yoshiro Shinozaki;Yoko Takahari;Noboru Kawabe;Noriaki Wakana;Keiji Umetani;Kikue Todoroki;Sayato Fukui;Chiharu Tanaka;Etsuro Tanaka;Hidezo Mori
目的脑穿通动脉（PA）血流改变可能与脑白色物质高信号的形成有关，我们研究了糖尿病大鼠模型PA与大脑中动脉（MCA）的血流动力学关系是否改变，与正常大鼠和去窦房神经大鼠模型比较方法我们使用单色同步辐射的微血管造影术以4.5 μm分辨率测量五组大鼠的PA和MCA的直径：（i）Long-Evans德岛大冢（LETO）;（ii）大冢Long-Evans德岛胖子（2型糖尿病伴肥胖模型）;（iii）LETO伴窦主动脉去神经支配（LETO + SAD）; ㈣ F344;和（v）F344 +链脲霉素结果与LETO相比，大冢Long-Evans德岛肥胖大鼠显示PA和MCA的直径显著减小，尽管PA/MCA直径比没有变化。与LETO组相比，LETO + SAD组MCA直径增大，PA/MCA直径比值减小。与F344大鼠相比，F344 +链脲佐菌素组MCA直径增大，PA/MCA直径比值减小。散点图显示，PA和MCA的直径基本上是相互独立的，在两种类型的糖尿病models.ConclusionPA一贯可视化的高分辨率通过微血管造影使用同步辐射。目前的结果表明，大鼠糖尿病模型显示PA直径和PA/MCA直径比的变化，这可能与糖尿病相关脑白色物质高信号的发展有关。Geriatr Gerontol Int 2015; 15（Suppl. 1）：74-80。
AimAs altered blood flow in the cerebral perforating arteries (PA) might be related to development of cerebral white matter hyperintensities, we examined whether the hemodynamic relationship of the PA and middle cerebral artery (MCA) is altered in rat models of diabetes, compared with normal rats and a rat model of sinoatrial denervation (blood pressure fluctuation model).MethodsWe used microangiography with monochromatic synchrotron radiation to measure the diameters of the PA and MCA at 4.5 μm resolution in five groups of rats: (i) Long‐Evans Tokushima Otsuka (LETO); (ii) Otsuka Long‐Evans Tokushima Fatty (a model of type 2 diabetes with obesity); (iii) LETO with sinoaortic denervation (LETO + SAD); (iv) F344; and (v) F344 + streptozotocin (a model of type 1 diabetes).ResultsCompared with LETO, Otsuka Long‐Evans Tokushima Fatty rats showed a significant reduction in the diameter of both PA and MCA, though the PA/MCA diameter ratio was unchanged. In contrast, compared with LETO, LETO + SAD rats showed an increased MCA diameter, and the PA/MCA diameter ratio was decreased. Compared with F344 rats, the MCA diameter was increased in F344 + streptozotocin rats, and the PA/MCA diameter ratio was decreased. Scatter diagrams showed that the diameters of the PA and MCA were essentially independent of each other in the two types of diabetic models.ConclusionPA were consistently visualized at high resolution by means of microangiography using synchrotron radiation. The present results show that rat diabetic models exhibit changes in PA diameter and PA/MCA diameter ratio, which might be related to the development of diabetes‐associated cerebral white matter hyperintensities.Geriatr Gerontol Int 2015; 15 (Suppl. 1): 74–80.