Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine.
Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine.
复制标题
DOI：
10.1016/j.gendis.2014.07.001
复制
发表时间：
2014-09-01
期刊：
影响因子：
6.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhang D;Wei G;Li P;Zhou X;Zhang Y
已经开发了用自体体细胞产生并接种在生物可降解或水凝胶支架上的工程化功能器官或组织，用于患有先天性疾病、感染、辐射或癌症的组织损伤的个体。然而，在这些患者中，通过活检从受损组织中获得的异常细胞可能会污染工程组织。因此，用于构建新器官或损伤或患病组织的功能恢复的替代细胞来源将是有用的。最近，我们在尿液中发现了干细胞。这些细胞是高度可扩展的，并且具有自我更新能力、旁分泌特性和多分化潜能。尿源性干细胞（urine-derived stem cells，USCs）作为一种新的细胞来源，来源于泌尿系统，在细胞治疗和组织工程中具有重要的应用价值。重要的是，USCs可以通过非侵入性，简单和低成本的方法获得，并高效诱导分化为三种真皮细胞系。
Engineered functional organs or tissues, created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds, have been developed for use in individuals with tissue damage suffered from congenital disorders, infection, irradiation, or cancer. However, in those patients, abnormal cells obtained by biopsy from the compromised tissue could potentially contaminate the engineered tissues. Thus, an alternative cell source for construction of the neo-organ or functional recovery of the injured or diseased tissues would be useful. Recently, we have found stem cells existing in the urine. These cells are highly expandable, and have self-renewal capacity, paracrine properties, and multi-differentiation potential. As a novel cell source, urine-derived stem cells (USCs) provide advantages for cell therapy and tissue engineering applications in regeneration of various tissues, particularly in the genitourinary tract, because they originate from the urinary tract system. Importantly, USCs can be obtained via a non-invasive, simple, and low-cost approach and induced with high efficiency to differentiate into three dermal cell lineages.