Calcium-sensing receptor regulation of renal mineral ion transport
Calcium-sensing receptor regulation of renal mineral ion transport
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DOI：
10.1016/j.ceca.2003.10.016
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发表时间：
2004-03-01
期刊：
影响因子：
4
通讯作者：
Friedman, PA
中科院分区：
文献类型：
--
作者：
Ba, JM;Friedman, PA
人们早就知道细胞外钙会影响肾钙和磷酸盐回收的速度和程度。在这篇综述中，我们根据我们目前对钙敏感受体（CaSR）肾小管定位的理解来考虑其中的一些发现。描述了直接涉及 CaSR 调节钙和磷酸盐转运的实验。这些结果表明 CaSR 在调节皮质厚升肢的 PTH 依赖性钙吸收和 PTH 敏感的近端小管磷酸盐转运中发挥重要作用。建议进一步调查的可能途径。 (C) 2003 Elsevier Ltd. 保留所有权利。
Extracellular calcium has long been known to affect the rate and magnitude of renal calcium and phosphate recovery. In this review, we consider some of these findings in light of our present understanding of the tubular localization of the calcium-sensing receptor (CaSR). Experiments directly implicating the CaSR in regulating calcium and phosphate transport are described. These results point to an important role of the CaSR in regulating PTH-dependent calcium absorption by cortical thick ascending limbs and on PTH-sensitive proximal tubule phosphate transport. Possible avenues for further investigation are suggested. (C) 2003 Elsevier Ltd. All rights reserved.