Interaction between the BDNF rs11030101 genotype and job stress on cognitive empathy
Interaction between the BDNF rs11030101 genotype and job stress on cognitive empathy
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BDNF rs11030101 基因型与工作压力对认知共情的相互作用
DOI：
10.1016/j.jad.2022.04.054
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发表时间：
2022-04-22
影响因子：
6.6
通讯作者：
Zhang，Xiang Yang
中科院分区：
文献类型：
--
作者：
Duan，Yuzhong;Li，Yuling;Zhang，Xiang Yang
背景共情是指个体在社会交往中体验他人情感和认知过程的能力。虽然许多研究已经研究了遗传变异对情绪共情的影响，但目前对遗传因素是否会影响认知共情知之甚少。本研究采用横断面设计，在北京某大学选取340名被试，探讨了BDNFrs11030101基因型与工作压力、共情尤其是认知共情的关系。人际反应指数（IRI）被用来测量共情。工作压力的测量使用House和Rizzo的工作压力量表。结果性别和年龄与各种IRI分量表相关（p< 0.001）。在控制性别、年龄和文化程度后，BDNFrs11030101基因型对共情各分量表均无主效应（p> 0.05）。工作压力与观点采择呈负相关（p= 0.006），与个人苦恼呈正相关（p< 0.001）。此外，BDNFrs11030101基因型调节了工作压力和幻想之间的关系（p= 0.013），表明T等位基因携带者在较高的工作压力下有较高的幻想得分，在较低的工作压力下有较低的幻想得分比AA纯合子。这种相互作用只存在于women.LimitationsThe样本量和单核苷酸多态性是有限的，和横截面designs.Conclusions女性大学教师与theBDNFrs11030101 T等位基因可能会利用更高的情感工作要求，从而培养他们的认知共情。
BackgroundEmpathy refers to an individual's ability to experience the emotional and cognitive processes of another person during social interactions. Although many studies have examined the effects of genetic variation on emotional empathy, little is currently known about whether genetic factors may influence cognitive empathy. This study investigated the relationship betweenBDNFrs11030101 genotype, job stress, and empathy, especially cognitive empathy, in a Chinese Han population.MethodsA cross-sectional design was used and 340 participants were recruited from a university in Beijing. Interpersonal Reactivity Index (IRI) was used to measure empathy. Job stress was measured using House and Rizzo's Job Stress Scale. TheBDNFrs11030101 was genotyped in all participants.ResultsGender and age were associated with various IRI subscales (p< 0.001). After controlling for gender, age and education level,BDNFrs11030101 genotype had no main effect on all empathy subscales (p> 0.05). Job stress was negatively associated with Perspective Taking (p= 0.006) and positively associated with Personal Distress (p< 0.001). In addition, theBDNFrs11030101 genotype modulated the relationship between job stress and Fantasy (p= 0.013), indicating that T allele carriers had higher Fantasy scores at higher job stress and lower Fantasy scores at lower job stress than AA homozygotes. This interaction was only present in women.LimitationsThe sample size and single-nucleotide polymorphism are limited, and the cross-sectional design should be improved.ConclusionsFemale university faculty with theBDNFrs11030101 T allele may utilize higher emotional job demands, thereby fostering their cognitive empathy.