White matter microstructural variability linked to differential attentional skills and impulsive behavior in a pediatric population.
White matter microstructural variability linked to differential attentional skills and impulsive behavior in a pediatric population.
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DOI：
10.1093/cercor/bhac180
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发表时间：
2022-05
期刊：
影响因子：
3.7
通讯作者：
A. Gagnon;G. Grenier;C. Bocti;V. Gillet;A. Baccarelli;J. Posner;M. Descoteaux;L. Takser
中科院分区：
文献类型：
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作者：
A. Gagnon;G. Grenier;C. Bocti;V. Gillet;A. Baccarelli;J. Posner;M. Descoteaux;L. Takser
结构和功能磁共振成像（MRI）研究表明，神经解剖学基础可能是注意力缺陷多动障碍（ADHD）的基础，但解剖学基础仍然未知。此外，在一般儿科人群中，与注意力和冲动性相关的白色物质（WM）微观结构的作用仍然没有得到很好的理解。使用基于提取WM连接及其子部分的Brainnetome图谱的最先进的结构连接管道，我们应用降维技术来获得生物学上可解释的WM措施。我们选择了前10名的连接的利益（位于额叶，顶叶，枕叶和基底神经节区域）与强大的解剖和统计标准。我们在171名儿童（27名Dx ADHD，3Dx ASD，9-13岁）中将WM测量与心理测量测试指标（Conner连续性能测试3）进行了相关性研究，这些儿童来自基于人群的GESTation和环境队列。我们发现，具有较低微结构复杂性和较低轴突密度的儿童在这些连接上表现出较高的冲动行为。当在小节中分割每个连接时，我们报告了位于一个或两个端点的WM改变，反映了WM改变沿着每个连接的特定定位。这些结果为理解一般人群中注意力和冲动性的神经生理学提供了新的见解。
Structural and functional magnetic resonance imaging (MRI) studies have suggested a neuroanatomical basis that may underly attention-deficit-hyperactivity disorder (ADHD), but the anatomical ground truth remains unknown. In addition, the role of the white matter (WM) microstructure related to attention and impulsivity in a general pediatric population is still not well understood. Using a state-of-the-art structural connectivity pipeline based on the Brainnetome atlas extracting WM connections and its subsections, we applied dimensionality reduction techniques to obtain biologically interpretable WM measures. We selected the top 10 connections-of-interests (located in frontal, parietal, occipital, and basal ganglia regions) with robust anatomical and statistical criteria. We correlated WM measures with psychometric test metrics (Conner's Continuous Performance Test 3) in 171 children (27 Dx ADHD, 3Dx ASD, 9-13 years old) from the population-based GESTation and Environment cohort. We found that children with lower microstructural complexity and lower axonal density show a higher impulsive behavior on these connections. When segmenting each connection in subsections, we report WM alterations localized in one or both endpoints reflecting a specific localization of WM alterations along each connection. These results provide new insight in understanding the neurophysiology of attention and impulsivity in a general population.