Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.
Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.
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DOI：
10.1111/cas.13196
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发表时间：
2017-04
期刊：
影响因子：
5.7
通讯作者：
Enomoto T
中科院分区：
文献类型：
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作者：
Yamawaki K;Ishiguro T;Mori Y;Yoshihara K;Suda K;Tamura R;Yamaguchi M;Sekine M;Kashima K;Higuchi M;Fujii M;Okamoto K;Enomoto T
性别决定区Y-box 2(SOX2)是参与胚胎干细胞自我更新和多能性的重要因子，在多种类型的癌症中具有细胞存活和进展的功能。在这里，我们发现一些子宫内膜癌细胞株表达SOX2，这是细胞生长所必需的。此外，在表达SOX2的子宫内膜癌细胞系中，SOX2过表达调控细胞周期蛋白依赖性激酶抑制因子1A(CDKN1A)的表达，并且SOX2与p21启动子DNA特异性结合。子宫内膜癌组织中SOX2的表达与组织学分级及预后不良密切相关。此外，在晚期子宫内膜癌患者中，低p21和高SOX2表达与患者最不利的预后相关。提示同时检测子宫内膜癌组织中SOX2和p21的表达可能是判断患者预后的有用生物标志物。
Sex‐determining region Y‐box 2 (SOX2) is an essential factor involved in the self‐renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin‐dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions in advanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis.