Obesity and risk of cancer in Japan
Obesity and risk of cancer in Japan
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DOI：
10.1002/ijc.20529
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发表时间：
2005-01-01
影响因子：
6.4
通讯作者：
Tsuji, I
中科院分区：
文献类型：
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作者：
Kuriyama, S;Tsubono, Y;Tsuji, I
我们在日本进行了一项基于人群的前瞻性队列研究，以检查身体质量指数（BMI）与任何癌症和个别部位癌症发病率之间的关系。体重指数是根据自我控制的体重和身高计算的。在多变量比例风险模型中计算相对风险（RR）和95%置信区间（CI）。在1984年入组时年龄在40岁或以上的27,539人中（15,054名女性和12,485名男性）没有癌症，在9年的随访期间，1,672人（668名女性和1004名男性）患上了癌症。在女性中，在对潜在混杂因素进行校正后，相对于BMI为18.5-24.9的人群，与不同BMI相关的所有癌症的RR为：BMI = 25.0-27.4的人群为1.04 (95% CI = 0.85-1.27), BMI = 27.5-29.9的人群为1.29 (1.00-1.68)，BMI大于或等于30.0的人群为1.47(1.06-2.05)（趋势p = 0.007）。较高的身体质量指数与女性患结直肠癌、乳腺癌（绝经后）、子宫内膜癌和胆囊癌的风险也显著相关。在男性中，我们观察到只有不吸烟的人患所有癌症的风险显著增加。超重和肥胖可能占女性任何癌症风险的4.5%（所有受试者）或6.2%（从不吸烟者），男性为-0.2%（所有受试者）或3.7%（从不吸烟者）。女性的这一数值在西方国家报告的女性中处于范围内（3.2%-8.8%）。我们的数据表明，超重是日本女性患癌症的主要风险因素。(C) 2004 Wiley-Liss, Inc。
We conducted a population-based prospective cohort study in Japan to examine the relationship between body mass index (BMI) and the risk of incidence of any cancer and of cancer at individual sites. Body mass index was calculated from self-administered body weight and height at baseline. Relative risks (RR) and 95% confidence intervals (CI) were calculated in multivariate proportional-hazards models. Among 27,539 persons (15,054 women and 12,485 men) aged 40 years or older who were free of cancer at enrollment in 1984, 1,672 (668 women and 1 004 men) developed cancer during 9 years of follow-up. In women, after adjustment for potential confounders, the RR of all cancers associated with different BMI, relative to a BMI of 18.5-24.9, were 1.04 (95% CI = 0.85-1.27) for BMI = 25.0-27.4,1.29 (1.00-1.68) for BMI = 27.5-29.9 and 1.47 (1.06-2.05) for BMI greater than or equal to 30.0 (p for trend = 0.007). Higher BMI was also significantly associated with higher risk of cancers of the colorectum, breast (postmenopausal), endometrium and gallbladder in women. In men, we observed significantly increased all-cancer risk among only never-smokers. Overweight and obesity could account for 4.5% (all subjects) or 6.2% (never-smokers) of the risk of any cancer in women and -0.2% (all subjects) or 3.7% (never-smokers) in men. The value for women was within the range among women reported from Western populations (3.2%-8.8%). Our data demonstrate that excess weight is a major cancer risk among Japanese women. (C) 2004 Wiley-Liss, Inc.