A Case of Tuberculosis Cutis Orificialis with Perianal Involvement
A Case of Tuberculosis Cutis Orificialis with Perianal Involvement
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DOI：
10.5021/ad.2009.21.4.443
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发表时间：
2009-11-01
影响因子：
1.6
通讯作者：
Yoon, Moon Soo
中科院分区：
文献类型：
--
作者：
Choi, Se Rim;Kim, Jin Ki;Yoon, Moon Soo
皮肤结核(TCO)是一种罕见的皮肤结核，是由晚期内科结核患者自身接种分枝杆菌引起的。TCO发生在口腔、肛周或生殖器粘膜及邻近皮肤。舌头是最常见的受累部位，但肛周也会受到影响。患者男，39岁，有4个月肛周疼痛溃疡病史。组织病理学检查发现真皮内可见由上皮样细胞和朗汉斯型巨细胞组成的肉芽肿样浸润物，Ziehl-Neelsen染色可见少数抗酸杆菌。聚合酶链式反应(聚合酶链式反应)对结核分枝杆菌呈阳性反应，胸片显示双上肺区活动性肺结核的结果一致。在开始使用抗结核药物治疗2个月后，皮损完全消失。我们报告一位活动性肺结核患者的肛周累及TCO的病例。(Ann Dermatol 21(4)443类似于446,2009)
Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis that is caused by auto-inoculation of mycobacteria in patients with advanced internal tuberculosis. TCO occurs in oral, perianal, or genital mucosa and adjacent skin. The tongue is the most frequently affected site, but the perianal area can also be affected. A 39-year-old male presented with a 4-month history of painful ulcers on the perianal area. The histopathologic findings revealed granulomatous infiltrates composed of epithelioid cells and Langhans-type giant cells in the dermis, and a few acid-fast bacilli noted on Ziehl-Neelsen staining. The polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis and the chest X-ray showed findings consistent with active pulmonary tuberculosis in both upper lung zones. The skin lesion showed complete resolution 2 months after the start of treatment with antituberculosis agents. We report a case of TCO with perianal involvement in a patient with underlying active pulmonary tuberculosis. (Ann Dermatol 21(4) 443 similar to 446, 2009)