Myoblast transplantation for heart failure
Myoblast transplantation for heart failure
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DOI：
10.1016/s0140-6736(00)03617-5
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发表时间：
2001-01-27
期刊：
影响因子：
168.9
通讯作者：
Marolleau, JP
中科院分区：
文献类型：
--
作者：
Menasché, P;Hagège, AA;Marolleau, JP
心肌内骨骼肌移植已被实验证明可以改善梗死后的心功能。我们报告了一个严重缺血性心力衰竭患者的成功经验。在冠状动脉旁路移植术中，将自体骨骼肌成肌细胞植入梗死后瘢痕中。5个月后，超声心动图和正电子发射断层扫描显示移植瘢痕收缩和存活。虽然这一结果令人鼓舞，但还需要更多的研究来验证。
Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic heart failure. Wa implanted autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas. 5 months later, there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography. Although this result is encouraging, it requires validation by additional studies.