Erectile dysfunction as a coronary artery disease risk equivalent
Erectile dysfunction as a coronary artery disease risk equivalent
复制标题
DOI：
10.1016/j.nuclcard.2008.07.006
复制
发表时间：
2008-11-01
影响因子：
2.4
通讯作者：
O'Keefe, James H.
中科院分区：
文献类型：
--
作者：
Lee, John H.;Ngengwe, Raphael;O'Keefe, James H.
背景使患者易患勃起功能障碍的条件与冠状动脉疾病的危险因素基本相似，包括糖尿病、高血压、高脂血症、肥胖、久坐不动的生活方式、抑郁症、年龄和吸烟。由于这些共同的风险和重叠的病理生理机制，我们设计了这个试点研究，以解决的假设，即冠状动脉钙的存在，一个已知的心脏风险增加的指标，与勃起功能障碍。一项前瞻性登记研究招募了9150名接受多探测器计算机断层扫描的男性。受试者提供了关于人口统计学变量、冠状动脉危险因素和勃起功能障碍症状或缺乏这些症状的基线数据。然后，对两组患者进行计算机断层扫描，以筛查冠状动脉钙的存在或不存在。与无勃起功能障碍的男性相比，勃起功能障碍的受试者年龄较大，甘油三酯水平较高，血压较高，更可能有可测量的冠状动脉钙化（79% vs 58%，P
Background. The conditions that predispose patients to erectile dysfunction are substantially similar to the coronary artery disease risk factors, including diabetes mellitus, hypertension, hyperlipidemia, obesity, sedentary lifestyle, depression, age, and smoking. Because of these shared risks and overlapping pathophysiologic mechanisms, we designed this pilot study to address the hypothesis that the presence of coronary artery calcium, a known indicator of increased cardiac risk, is associated with erectile dysfunction.Methods and Results. A prospective registry enrolled 9150 men who underwent multidetector computed tomography. Subjects supplied baseline data regarding demographic variables, coronary risk factors, and erectile dysfunction symptoms or lack thereof. The 2 groups then underwent computed tomography to screen for the presence or absence of coronary artery calcium. Subjects with erectile dysfunction were older, had higher triglyceride levels, had higher blood pressures, and were more likely to have measurable coronary artery calcification than men without erectile dysfunction (79% vs 58%, P