Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders
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DOI：
10.1080/01616412.2016.1251711
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发表时间：
2017-01-01
影响因子：
1.9
通讯作者：
Islam, Md. Torequl
中科院分区：
文献类型：
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作者：
Islam, Md. Torequl
活性物质在生理功能中起着重要作用。活性物质的过量产生，特别是活性氧（ROS）和活性氮（RNS）物质，以及身体抗氧化酶系统平衡失调，会导致细胞结构、脂质、蛋白质以及诸如DNA和RNA等遗传物质的破坏。此外，活性物质对线粒体及其代谢过程的影响最终会导致ROS/RNS水平升高，从而引起线粒体蛋白质、脂质和DNA的氧化。氧化应激被认为与许多疾病的病因有关，包括神经退行性疾病（NDDs），如阿尔茨海默病、肌萎缩侧索硬化症、弗里德赖希共济失调、亨廷顿病、多发性硬化症和帕金森病。此外，导致蛋白质错误折叠的氧化应激可能引发其他神经退行性疾病，包括克雅氏病、牛海绵状脑病、库鲁病、格斯特曼 - 施特劳斯勒 - 谢inker综合征和致命性家族性失眠症。本综述总结了与氧化应激和线粒体功能障碍相关的神经退行性疾病的概况。
Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's diseases. In addition, oxidative stress causing protein misfold may turn to other NDDs include Creutzfeldt-Jakob disease, Bovine Spongiform Encephalopathy, Kuru, Gerstmann-Straussler-Scheinkersyndrome, and Fatal Familial Insomnia. An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review.