CALCIUM SUPPLEMENTATION AND BONE-MINERAL DENSITY IN ADOLESCENT GIRLS
CALCIUM SUPPLEMENTATION AND BONE-MINERAL DENSITY IN ADOLESCENT GIRLS
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DOI：
10.1001/jama.270.7.841
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发表时间：
1993-08-18
影响因子：
120.7
通讯作者：
KULIN, HE
中科院分区：
文献类型：
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作者：
LLOYD, T;ANDON, MB;KULIN, HE
客观。-评价补钙对青春期白色女孩骨获得的影响。一项关于18个月补钙对骨密度和骨量影响的随机、双盲、安慰剂对照试验。研究入组时平均年龄为11.9 ± 0.5岁的94名女孩。在一个小镇上的大学医院。介入治疗。钙补充剂，500毫克/天钙柠檬酸苹果酸钙;对照组接受安慰剂药丸。采用双能X线吸收法和24小时尿钙排泄法测定腰椎和全身的骨密度和骨矿含量。整个研究组从饮食来源摄入的钙平均为960 mg/d。补充组平均每天额外摄入354 mg钙。补充组与安慰剂组相比，腰椎骨密度增加更大（18.7% vs 15.8%; P=.03），腰椎骨矿物质含量（39.4% vs 34.7%; P= 0.06），全身骨密度（9.6% vs 8.3%; P= 0.05）和24小时尿钙排泄量（90.4 vs 72.9 mg/d; P= 0.02）。通过补充柠檬酸苹果酸钙，将每日钙摄入量从推荐每日摄入量的80%增加到110%，导致青春期女孩全身和脊柱骨密度显著增加。补充组中每年增加24 g的骨增量转化为青少年生长期间每年额外增加1.3%的骨骼质量，这可能为未来的骨质疏松性骨折提供保护。
Objective.-To evaluate the effect of calcium supplementation on bone acquisition in adolescent white girls.Design.-A randomized, double-blind, placebo-controlled trial of the effect of 18 months of calcium supplementation on bone density and bone mass.Subjects.-Ninety-four girls with a mean age of 11.9+0.5 years at study entry.Setting.-University hospital in a small town.Interventions.-Calcium supplementation, 500 mg/d calcium as calcium citrate malate; controls received placebo pills.Main Outcome Measures.-Bone mineral density and bone mineral content of the lumbar spine and total body were measured by dual-energy x-ray absorptiometry and calcium excretion from 24-hour urine specimens.Results.-Calcium intake from dietary sources averaged 960 mg/d for the entire study group. The supplemented group received, on average, an additional 354 mg/d of calcium. The supplemented group compared with the placebo group had greater increases of lumbar spine bone density (18.7% vs 15.8%; P=.03), lumbar spine bone mineral content (39.4% vs 34.7%; P=.06), total body bone mineral density (9.6% vs 8.3%; P=.05), and 24-hour urinary calcium excretion (90.4 vs 72.9 mg/d; P=.02), respectively.Conclusions.-Increasing daily calcium intake from 80% of the recommended daily allowance to 110% via supplementation with calcium citrate malate resulted in significant increases in total body and spinal bone density in adolescent girls. The increase of 24 g of bone gain per year among the supplemented group translates to an additional 1.3% skeletal mass per year during adolescent growth, which may provide protection against future osteoporotic fracture.