In vivo efficacy of fluoroquinolones against systemic tularaemia infection in mice
In vivo efficacy of fluoroquinolones against systemic tularaemia infection in mice
复制标题
DOI：
10.1093/jac/dki359
复制
发表时间：
2005-12-01
影响因子：
5.2
通讯作者：
Brooks, TJG
中科院分区：
文献类型：
--
作者：
Piercy, T;Steward, J;Brooks, TJG
目的：环丙沙星，加替沙星和阿替沙星的体内疗效进行了评估，在实验性的土拉热弗朗西丝菌Schu S4感染的BALB/c小鼠model.Methods：小鼠口服抗生素100 mg/kg，每天两次开始在6，24或48小时后暴露，并持续暴露后14天。所有小鼠皮下接种1 × 10（6）cfu F。结果：暴露后6 h开始治疗，环丙沙星、加替沙星和阿托沙星的存活率分别为94%、100%和100%。当治疗延迟至暴露后24小时时，存活率为环丙沙星67%，加替沙星96%和阿托沙星100%。在暴露后48小时开始的治疗导致环丙沙星治疗小鼠的存活率显著降低，存活率为0%，相比之下，加替沙星和阿托沙星分别为84%和62%。未处理的感染对照小鼠在暴露后96小时内死亡。结论：加替沙星和利福沙星均能有效地预防感染动物的死亡率，可作为治疗全身性氟喹诺酮类药物的替代抗生素。土拉菌感染
Objectives: The in vivo efficacy of ciprofloxacin, gatifloxacin and moxifloxacin were assessed in an experimental Francisella tularensis Schu S4 infection in the BALB/c mouse model.Methods: Mice were given 100 mg/kg of antibiotic by oral administration twice daily commencing at 6, 24 or 48 h post-exposure and continued for 14 days post-exposure. All mice were challenged subcutaneously with 1 x 10(6) cfu F. tularensis Schu S4 and observed for a period of 56 days.Results: Treatment initiated 6 h post-exposure resulted in 94, 100 and 100% survival for ciprofloxacin, gatifloxacin and moxifloxacin, respectively. When treatment was delayed until 24 h post-exposure the survival rates were ciprofloxacin 67%, gatifloxacin 96% and moxifloxacin 100%. Treatment initiated at 48 h post-exposure resulted in a significant reduction in the survival rate of the ciprofloxacin-treated mice, with 0% survival compared with 84 and 62% for gatifloxacin and moxifloxacin, respectively. Non-treated infected control mice died within 96 h post-exposure. Dexamethasone given at day 42 for 7 days to suppress the animals' immune system caused relapse in all of the treatment groups.Conclusions: Both gatifloxacin and moxifloxacin were more effective at preventing mortality than ciprofloxacin and could be considered as alternative antibiotics in the treatment of systemic F. tularensis infection.