Pathogenesis of the rubella exanthem: distribution of rubella virus in the skin during rubella with and without rash.
Pathogenesis of the rubella exanthem: distribution of rubella virus in the skin during rubella with and without rash.
复制标题
风疹疹的发病机制：有或没有皮疹的风疹期间，风疹病毒在皮肤中分布。
DOI：
10.1093/infdis/137.1.74
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
A. D. Heggie
中科院分区：
文献类型：
--
作者：
A. D. Heggie
在先前对风疹病毒在风疹发病机制中作用的评估中，始终从风疹的皮肤活检标本的细胞培养中分离到病毒，并得出结论，皮肤中存在病毒对风疹的演变是必不可少的。为了确定病毒是否仅在与皮疹相关的皮肤中存在，同时对有皮疹和无皮疹的皮肤进行穿孔活检。在16例患者的配对皮肤标本中，12例从皮疹部位分离到病毒，10例从非皮损皮肤分离到病毒。另1例从皮肤中分离到病毒，经血清学反应和咽部病毒检测显示风疹未出现皮疹。结论是，风疹病毒在风疹患者的皮肤中广泛传播，无论皮疹的存在或分布如何，尽管风疹病毒在皮肤中的存在是风疹的一个恒定特征，但它只是风疹发病的因素之一。
In a previous assessment of the role of rubella virus in the pathogenesis of the rubella exanthem, virus was consistently isolated from cell cultures of skin biopsy specimens of the rash, and it was concluded that presence of virus in the skin was essential to evolution of the rash. For determination of whether virus is present in the skin only in association with rash, punch biopsies were performed concurrently on areas of skin with and without rash. Among paired skin specimens of 16 patients, virus was isolated from sites of rash in 12 and from the uninvolved skin in 10. In another patient, shown by serologic response and recovery of virus from the pharynx to have rubella without a rash, virus was also isolated from the skin. It is concluded that rubella virus is widely disseminated in the skin of patients with rubella irrespective of the presence or distribution of the rash, and that the presence of virus in the skin, although a constant feature of the disease, is only one of the factors involved in the pathogenesis of the exanthem.