Longitudinal Amyloid Imaging Using 11C-PiB: Methodologic Considerations
Longitudinal Amyloid Imaging Using 11C-PiB: Methodologic Considerations
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DOI：
10.2967/jnumed.112.113654
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发表时间：
2013-09-01
影响因子：
9.3
通讯作者：
Boellaard, Ronald
中科院分区：
文献类型：
--
作者：
van Berckel, Bart N. M.;Ossenkoppele, Rik;Boellaard, Ronald
有几种方法用于分析C-11-匹兹堡化合物B(C-11-PIB)的数据。本研究的目的是确定测量特定C-11-PIB结合的纵向变化的选择方法。方法：对7例阿尔茨海默病(AD)患者、11例轻度认知障碍(MCI)患者和11例健康对照组进行90min C-11-PIB基线动态扫描和随访(30+/-5mo)。使用参考参数标测(RPM2)、参考Logan值和标准化摄取值体积比(SUVR)生成参数图像，后者在注射后60-90(SUVR(60-90))和40-60(SUVR(40-60))之间间隔。在所有分析中，以小脑灰质作为参照区。使用基于概率图的模板来定义感兴趣的全球皮质体积。得出所有分析方法的基线和随访之间的百分比变化。结果：与RPM2相比，SUVR(60-90)和SUVR(40-60)分别高估了结合强度13%和10%。参考Logan值平均比RPM2低6%。两种超高分辨率测量都显示出较高的受试者间变异性。随着时间的推移，AD患者大脑皮质相对于小脑的示踪剂输送R-1减少(P<；0.05)，但在MCI患者和对照组中没有下降。模拟表明，UVR，而不是RPM2和参考洛根值，高度依赖于摄取周期，并且SUVR随时间的变化对流量的变化很敏感。结论：要可靠地评估淀粉样蛋白随时间的结合情况--例如，在药物干预研究中--使用完全定量的方法进行数据采集和分析是至关重要的。
Several methods are in use for analyzing C-11-Pittsburgh compound-B (C-11-PiB) data. The objective of this study was to identify the method of choice for measuring longitudinal changes in specific C-11-PiB binding. Methods: Dynamic 90-min C-11-PiB baseline and follow-up scans (interval, 30 +/- 5 mo) were obtained for 7 Alzheimer disease (AD) patients, 11 patients with mild cognitive impairment (MCI), and 11 healthy controls. Parametric images were generated using reference parametric mapping (RPM2), reference Logan values, and standardized uptake value volume ratios (SUVr), the latter for intervals between 60 and 90 (SUVr(60-90)) and 40 and 60 (SUVr(40-60)) minutes after injection. In all analyses, cerebellar gray matter was used as a reference region. A global cortical volume of interest was defined using a probability map-based template. Percentage change between baseline and follow-up was derived for all analytic methods. Results: SUVr(60-90) and SUVr(40-60) overestimated binding with 13% and 10%, respectively, compared with RPM2. Reference Logan values were on average 6% lower than RPM2. Both SUVr measures showed high intersubject variability. Over time, R-1, the delivery of tracer to the cortex relative to that to the cerebellum, decreased in AD patients (P < 0.05) but not in MCI patients and controls. Simulations showed that SUVr, but not RPM2 and reference Logan values, was highly dependent on uptake period and that changes in SUVr over time were sensitive to changes in flow. Conclusion: To reliably assess amyloid binding over time-for example, in drug intervention studies-it is essential to use fully quantitative methods for data acquisition and analysis.