Spatiotemporal Complexity of the Aortic Sinus Vortex as a Function of Leaflet Calcification.
Spatiotemporal Complexity of the Aortic Sinus Vortex as a Function of Leaflet Calcification.
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主动脉窦涡的时空复杂性作为小叶钙化的函数。
DOI：
10.1007/s10439-019-02224-1
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发表时间：
2019
影响因子：
3.8
通讯作者：
Dasi,LakshmiPrasad
中科院分区：
文献类型：
--
作者：
Hatoum,Hoda;Dasi,LakshmiPrasad
Several studies have shown the variation of aortic sinus structures’ hemodynamics with different flow and geometric characteristics. They have also correlated aortic sinus hemodynamics with the progression and evolution of calcific aortic valve disease (CAVD). This study aims at visualizing aortic sinus fluid structure variations as functions of different leaflet calcification degrees and assessing their potential relationship with CAVD. A degenerated 23 mm Carpentier-Edwards Perimount Magna valve extracted from a redo-surgery patient was implanted in an aortic root model and tested in a pulse duplicator left heart simulator. The valve has 3 leaflets with 3 different levels of calcium distribution: mild, moderate and severe. High-speed imaging and particle image velocimetry were performed to assess sinus vortices, leaflet tip position and velocity along with shear stress. Results have shown that (a) aortic sinus vortices initiation, entrapment and evolution varied with different calcified leaflet exposure; (b) higher velocities in the sinus were calculated with the mildly calcified leaflet compared to the moderately and severely calcified ones; (c) during systole, the mildly calcified leaflet sinus case shows the most spread-out and higher ranges of shear stress probabilities and highest magnitudes going from (− 1.5 to + 1.8 Pa) compared with (− 1.0 to + 1.0 Pa) for moderately and severely calcified leaflets. The higher the calcification degree the lower the shear stress range and likelihoods of having higher shear stress. This holds in diastole as well. This study shows the impact of calcification on the aortic sinus flow structures.
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用于独立组参数检验的四因素结构。
DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
P. Games
通讯作者：
P. Games
影响因子：
7.6
作者：
BENTLER, PM;SPECKART, G
通讯作者：
SPECKART, G
药物滥用：解释和解释模型的回顾。
DOI：
10.1300/j251v04n03_02
发表时间：
1985
期刊：
Advances in alcohol & substance abuse
影响因子：
--
作者：
D. Lettieri
通讯作者：
D. Lettieri
青少年的物质使用：种族、收入和可用性的影响。
DOI：
10.1300/j251v05n03_05
发表时间：
1986
期刊：
Advances in alcohol & substance abuse
影响因子：
--
作者：
Maddahian,E;Newcomb,MD;Bentler,PM
通讯作者：
Bentler,PM
青少年使用毒品的意图：纵向分析。
DOI：
--
发表时间：
1981
期刊：
International Journal of the Addictions
影响因子：
--
作者：
G. Huba;J. Wingard;P. Bentler
通讯作者：
P. Bentler