DIAGNOSTIC-CRITERIA FOR SCRUB TYPHUS - PROBABILITY VALUES FOR IMMUNOFLUORESCENT ANTIBODY AND PROTEUS OXK AGGLUTININ TITERS
DIAGNOSTIC-CRITERIA FOR SCRUB TYPHUS - PROBABILITY VALUES FOR IMMUNOFLUORESCENT ANTIBODY AND PROTEUS OXK AGGLUTININ TITERS
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DOI：
10.4269/ajtmh.1983.32.1101
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
GROVES, MG
中科院分区：
文献类型：
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作者：
BROWN, GW;SHIRAI, A;GROVES, MG
间接微量免疫荧光抗体（IFA）和Weil-Felix（OXK）测试的敏感性和特异性，以确定一系列的滴度使用组的患病和对照（其他发热性疾病）患者诊断的其他方法。在≥的截止点处，1：400时，IFA试验的特异性为0.96，在≥ 1：400时，IFA试验的特异性为0.96。1：320，OXK特异性为0.97。使用这些高度特异性的抗体水平或其他严格的诊断标准（分离或4倍滴度上升），在马来西亚农村医院的发热患者中，恙虫病感染的患病率被确定为0.22。正确诊断恙虫病的概率值（Pr），然后计算特异性，灵敏度和患病率确定的滴度范围。OXK滴度≥1：320为0.79，IFA效价≥ 1：320的Pr为0.79。1：400是0.78。当这两种滴度都存在于一份标本中时，Pr增加至0.96。
The sensitivities and specificities of the indirect microimmunofluorescent antibody (IFA) and Weil-Felix (OXK) tests for scrub typhus were established for a range of titers using groups of diseased and control (other febrile illnesses) patients diagnosed by other methods. At a cut-off point of .gtoreq. 1:400, the IFA test was 0.96 specific, and at .gtoreq. 1:320, the OXK was 0.97 specific. Using either these highly specific levels of antibody or other rigorous diagnostic criteria (isolation or 4-fold rising titers), the prevalence of scrub typhus infection was determined to be 0.22 in an unselected population of febrile patients in a rural Malaysian hospital. Probability values (Pr) for the correct diagnosis of scrub typhus were then calculated from the specificity, sensitivity and prevalence determination for a range of titers. The Pr for an OXK titer of .gtoreq. 1:320 was 0.79, and the Pr for an IFA titer of .gtoreq. 1:400 was 0.78. When both these titers were present in a single specimen, the Pr increased to 0.96.