Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis
Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis
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DOI：
10.1038/s41598-018-33813-0
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发表时间：
2018-10-19
影响因子：
4.6
通讯作者：
Meuric, Vincent
中科院分区：
文献类型：
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作者：
Boyer, Emile;Le Gall-David, Sandrine;Meuric, Vincent
遗传性血色病（GH）是铁超载的原因。增加的转铁蛋白饱和度（TSAT）与严重的牙周炎相关，牙周炎是影响牙齿周围组织的慢性炎症性疾病，并且与龈下微生物群的生态失调有关。由于铁是细菌病原体所必需的，铁稳态的改变可以驱动生态失调。为了阐明血清铁生物标志物和龈下微生物群之间的关系，我们分析了66例GH患者的样本。根据TSAT，微生物群的共现分析显示出非常不同的模式。健康和周围病原菌群被发现在TSAT正常的患者中竞争（
Genetic haemochromatosis (GH) is responsible for iron overload. Increased transferrin saturation (TSAT) has been associated with severe periodontitis, which is a chronic inflammatory disease affecting tissues surrounding the teeth and is related to dysbiosis of the subgingival microbiota. Because iron is essential for bacterial pathogens, alterations in iron homeostasis can drive dysbiosis. To unravel the relationships between serum iron biomarkers and the subgingival microbiota, we analysed samples from 66 GH patients. The co-occurrence analysis of the microbiota showed very different patterns according to TSAT. Healthy and periopathogenic bacterial clusters were found to compete in patients with normal TSAT (